FBXO25 and TBX5

Number of citations of the paper that reports this interaction (PubMedID 25725482)
2

Data Source:
BioGRID (pull down, pull down)

		FBXO25	TBX5
Description		F-box protein 25	T-box transcription factor 5
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Protein Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Morphogenesis Of An Epithelium Bundle Of His Development Atrioventricular Valve Morphogenesis Endocardial Cushion Development Cardiac Left Ventricle Formation Ventricular Septum Development Transcription Initiation From RNA Polymerase II Promoter Cell-cell Signaling Pattern Specification Process Heart Development Negative Regulation Of Cell Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Forelimb Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Pericardium Development Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Atrial Septum Morphogenesis Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation
Pathways			YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors
Drugs
Diseases			Holt-Oram syndrome
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Airflow obstruction ( 22837378) Atrial fibrillation ( 28416818 28416822 30061737 29892015) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood pressure ( 21909110) Bone mineral density (total hip) ( 29883787) Diastolic blood pressure ( 28135244 19430479 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diverticular disease ( 30177863) Electrocardiographic traits ( 20062063) FEV1 ( 30804560) Hypertension ( 30487518) Laryngeal squamous cell carcinoma ( 25194280) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Mean arterial pressure ( 30487518) Obesity-related traits ( 23251661) P wave duration ( 28794112) Peak expiratory flow ( 30804560) Percent mammographic density ( 22532574) PR interval ( 30046033 20062060 25035420 23139255 21347284) Prostate cancer ( 23535732 25939597) QRS duration ( 27577874 30012220 21076409) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Visceral fat ( 22589738)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX C19orf57 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	5 interacting genes: FBXO25 GATA4 KAT5 KDM6A NKX2-5
Entrez ID		26260	6910
HPRD ID		16439	03372
Ensembl ID		ENSG00000147364	ENSG00000089225
Uniprot IDs		A0A024QZ88 Q8TCJ0	Q99593
PDB IDs			2X6U 2X6V 4S0H 5BQD
Enriched GO Terms of Interacting Partners?
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