TES and TLN1

Number of citations of the paper that reports this interaction (PubMedID 12571287)
24

Data Source:
HPRD (in vivo, in vitro)

		TES	TLN1
Description		testin LIM domain protein	talin 1
Image
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Focal Adhesion Cell Junction Protein-containing Complex	Ruffle Extracellular Region Cell Cytosol Cytoskeleton Adherens Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Cadherin Binding	Phosphatidylserine Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Cell Proliferation	Platelet Degranulation Muscle Contraction Cytoskeletal Anchoring At Plasma Membrane Cell-cell Junction Assembly Cell-substrate Junction Assembly Integrin-mediated Signaling Pathway Viral Process Cortical Actin Cytoskeleton Organization Integrin Activation IRE1-mediated Unfolded Protein Response Platelet Aggregation
Pathways			Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		Chronotype ( 30696823) Glaucoma ( 31959993 30054594) Intraocular pressure ( 31959993 30054594 29235454) Metabolite levels ( 23823483)	IgE levels in asthmatics ( 23967269) Platelet distribution width ( 27863252)
Interacting Genes		13 interacting genes: ACTL7A ACTN1 ALKBH4 ARAP1 ENAH EVL GRIPAP1 SOCS3 SPOCK2 SPTAN1 TLN1 VASP ZYX	26 interacting genes: ACTA1 CDK5 DAG1 DOK1 EGFR ERBB2 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP PKD1 PTK2 PTK2B PXN SMURF1 TES TUBA1A VCL YWHAQ
Entrez ID		26136	7094
HPRD ID		05833	01726
Ensembl ID		ENSG00000135269	ENSG00000137076
Uniprot IDs		A4D0U5 Q9UGI8	Q9Y490
PDB IDs		2IYB 2XQN	1SYQ 2MWN 4DJ9 6R9T
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?