APPL1 and KLF15

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		APPL1	KLF15
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Kruppel like factor 15
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Macropinosome Extracellular Exosome Intracellular Vesicle	Nuclear Chromatin Cell Nucleus
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Glucose Import Positive Regulation Of Glucose Import Positive Regulation Of Melanin Biosynthetic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Cellular Glucose Homeostasis Regulation Of Transcription By RNA Polymerase II Glial Cell Differentiation Cardiac Muscle Hypertrophy In Response To Stress Response To Insulin Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Glomerular Visceral Epithelial Cell Differentiation Cellular Response To Peptide Negative Regulation Of Peptidyl-lysine Acetylation
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS			Macular telangiectasia type 2 ( 28250457) Male-pattern baldness ( 28196072) Manganese levels ( 26025379) Metabolite levels ( 23378610) Urate levels ( 31578528)
Interacting Genes		45 interacting genes: ADIPOR1 ADIPOR2 AKT1 AKT2 APPL2 BATF3 BRWD1 CBL CBLB CMTM4 DCC DOK2 DOK3 DOK7 DPYSL5 EGFR FARS2 FSHR HDAC2 ID1 IMPDH2 INO80E KLF15 KXD1 MAGEA9 MAGEC3 MAP3K1 MEOX1 MTA2 PIK3CA PIK3R1 PIK3R2 PLEKHF2 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 SCAPER SH2D2A SOCS6 TP53 TRAF2 UBE2O ZNF829	10 interacting genes: ANKS1A APPL1 CRK PIK3R3 PRKAB2 SNX13 STAT3 SUV39H1 TCF21 ZBTB24
Entrez ID		26060	28999
HPRD ID		05053	07568
Ensembl ID		ENSG00000157500	ENSG00000163884
Uniprot IDs		Q9UKG1	Q9UIH9
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B	2ENT
Enriched GO Terms of Interacting Partners?
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