LRIG1 and GLRX3

Number of citations of the paper that reports this interaction (PubMedID 29317492)
5

Data Source:
BioGRID (two hybrid)

		LRIG1	GLRX3
Description		leucine rich repeats and immunoglobulin like domains 1	glutaredoxin 3
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Matrix	Cell Nucleus Cytosol Cell Cortex Z Disc Dendrite
	Molecular Function		RNA Binding Protein Kinase C Binding Protein Binding Electron Transfer Activity Protein Disulfide Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding
	Biological Process	Sensory Perception Of Sound Hair Cycle Process Otolith Morphogenesis Innervation	Regulation Of The Force Of Heart Contraction Cellular Iron Ion Homeostasis Negative Regulation Of Cardiac Muscle Hypertrophy Electron Transport Chain [2Fe-2S] Cluster Assembly Cell Redox Homeostasis Protein Maturation By Iron-sulfur Cluster Transfer
Pathways		Signaling by EGFR Negative regulation of MET activity	Iron uptake and transport
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Antibody status in Tripanosoma cruzi seropositivity ( 24324551) Atrial fibrillation ( 30061737 29892015) Birth weight ( 31043758) Blood urea nitrogen levels ( 29403010) Carotid intima media thickness ( 21909108) Chronic kidney disease ( 29124443) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Creatinine levels ( 29124443) Estimated glomerular filtration rate ( 29124443) Hyperuricemia ( 29124443) Intraocular pressure ( 30054594) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Non-glioblastoma glioma ( 28346443) Pulse pressure ( 27841878) QRS duration ( 27577874 21076409 27659466) Renal function-related traits (BUN) ( 22797727) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Serum uric acid levels ( 29124443) Systolic blood pressure ( 27841878) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Alcohol dependence ( 26365420) Copper levels ( 26025379) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HIV-1 susceptibility ( 21160409) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Triglyceride levels x short total sleep time interaction (1df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		3 interacting genes: CBL GLRX3 ZBTB16	69 interacting genes: ADAMTSL4 ALKBH3 BCL6 BOLA1 CA9 CBLB CCHCR1 CGGBP1 CIAPIN1 EFEMP2 FAM118A FRA10AC1 GATA1 GMCL1 GRN HEXD IHO1 IKZF1 KRT31 KRT38 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 LCE2D LNX2 LRIG1 MAP3K3 MAPK6 MAPKBP1 MDFI MOXD1 NADK NOTCH2NLA OLFM3 PCSK5 PFDN5 PLEKHG4B PLSCR1 PRKCQ PRKCZ PRKD2 RGS20 SOX7 STAU1 TCF4 TLE5 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF148 ZNF23 ZNF426 ZNF512B ZNF544
Entrez ID		26018	10539
HPRD ID		10057	10153
Ensembl ID		ENSG00000144749	ENSG00000108010
Uniprot IDs		Q96JA1	A0A140VJK1 O76003
PDB IDs		4U7L 4U7M	2DIY 2WZ9 2YAN 3ZYW
Enriched GO Terms of Interacting Partners?
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