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SIN3A and TOPORS
Number of citations of the paper that reports this interaction (PubMedID
17803295
)
25
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
SIN3A
TOPORS
Description
SIN3 transcription regulator family member A
TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
Image
No pdb structure
GO Annotations
Cellular Component
Histone Deacetylase Complex
Kinetochore
Chromatin
Cell
Nucleus
Nucleoplasm
Transcription Factor Complex
Nucleolus
Sin3 Complex
Transcriptional Repressor Complex
Ubiquitin Ligase Complex
Spindle Pole
Gamma-tubulin Complex
Nucleus
Nucleoplasm
Centriole
Cytoplasmic Dynein Complex
PML Body
Nuclear Speck
Midbody
Photoreceptor Connecting Cilium
Ciliary Basal Body
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Transcription Corepressor Activity
RNA Binding
Histone Deacetylase Activity
Protein Binding
Protein Deacetylase Activity
Protein-containing Complex Binding
DNA Binding
Antigen Binding
Ubiquitin-protein Transferase Activity
Protein Binding
SUMO Transferase Activity
DNA Topoisomerase Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Hematopoietic Progenitor Cell Differentiation
DNA Replication
Protein Deacetylation
Aging
Regulation Of Hormone Levels
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Histone Deacetylation
Regulation Of Lipid Metabolic Process
Cerebral Cortex Neuron Differentiation
Regulation Of Axon Extension
Positive Regulation Of Chromatin Silencing
Cellular Protein Localization
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Response To Methylglyoxal
Cellular Response To Glucose Stimulus
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Histone H3-K27 Acetylation
Cellular Response To Dopamine
Negative Regulation Of Transcription Regulatory Region DNA Binding
Protein Polyubiquitination
Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Retina Layer Formation
Protein Sumoylation
Protein Localization To Nucleus
Photoreceptor Cell Outer Segment Organization
Regulation Of Cell Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Retinal Rod Cell Development
Retinal Cone Cell Development
Positive Regulation Of Ubiquitin-protein Transferase Activity
Maintenance Of Protein Location In Nucleus
Protein K48-linked Ubiquitination
Pathways
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
NoRC negatively regulates rRNA expression
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Factors involved in megakaryocyte development and platelet production
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of immune response proteins
Drugs
Diseases
Retinitis pigmentosa (RP)
GWAS
Estimated glomerular filtration rate (
31152163
)
Height (
20189936
)
Sudden cardiac arrest (
21658281
)
Early spontaneous preterm birth (
31194736
)
Immune response to smallpox vaccine (IL-6) (
22610502
)
Metabolite levels (
23823483
)
Interacting Genes
91 interacting genes:
ARID4A
ARID4B
BCL11A
BCL6
BCL6B
BHLHE40
BRMS1
BRMS1L
CBFA2T2
COPS2
CTBP1
CTCF
CUL4B
CYTOR
DACH1
DDB1
DDX20
DHX30
ETV6
FOXK2
H3-4
HBP1
HCFC1
HDAC1
HDAC2
HDAC7
HDAC9
HEY2
HTT
IKZF1
IKZF4
ING1
IRF5
KLF10
KLF11
KLF13
KLF16
KLF9
LRCH4
MAD1L1
MBD2
MBD4
MECP2
MEN1
MNT
MORF4L2
MXD1
MXD4
MXI1
MYB
NCOR2
NFKB1
NFKB2
NR2E3
OGT
PA2G4
PHB
PHF12
PML
PRMT5
PTMA
RBBP4
RBBP7
RBP1
RBPJ
REL
RELA
RELB
RLIM
RUNX1T1
SAP18
SAP30
SETDB1
SFPQ
SKI
SMAD3
SMARCA4
SMARCC1
SMARCE1
SNW1
SPI1
STAT3
SYT1
TAL1
TFCP2
TGIF1
THAP11
TOPORS
TP53
TRIM28
ZBTB16
28 interacting genes:
CASP8
CREBBP
EPM2A
H2AX
HABP4
MTDH
NKX3-1
SATB1
SERBP1
SIN3A
SNIP1
SPOP
SUMO1
SUMO2
TOP1
TP53
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2I
UBE2J1
UBE2L6
UBE2N
UBE2W
XRCC1
Entrez ID
25942
10210
HPRD ID
09690
11642
Ensembl ID
ENSG00000169375
ENSG00000197579
Uniprot IDs
Q96ST3
Q9NS56
PDB IDs
1PO4
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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