RAB26 and GCH1

Number of citations of the paper that reports this interaction (PubMedID 16696853)
14

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RAB26	GCH1
Description		RAB26, member RAS oncogene family	GTP cyclohydrolase 1
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GO Annotations	Cellular Component	Golgi Membrane Endomembrane System Secretory Granule Membrane Intrinsic Component Of Plasma Membrane Anchored Component Of Synaptic Vesicle Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus
	Molecular Function	GTPase Activity Protein Binding GTP Binding GMP Binding	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Coenzyme Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Intracellular Protein Transport Regulation Of Exocytosis Rab Protein Signal Transduction Exocrine System Development Golgi To Plasma Membrane Protein Transport Regulated Exocytosis Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Cofactor Metabolic Process Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals
Pathways		RAB geranylgeranylation	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Isopropyl Alcohol Guanine
Diseases			Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS			Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963)
Interacting Genes		3 interacting genes: APP GCH1 RIMS1	14 interacting genes: AHSA1 ATP1B1 ATP6V1A CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 YWHAZ
Entrez ID		25837	2643
HPRD ID		05676	02573
Ensembl ID		ENSG00000167964	ENSG00000131979
Uniprot IDs		Q9ULW5	A0A024R642 P30793 Q8IZH9
PDB IDs		2G6B	1FB1
Enriched GO Terms of Interacting Partners?
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