FTH1 and KPNA2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		FTH1	KPNA2
Description		ferritin heavy chain 1	karyopherin subunit alpha 2
Image
GO Annotations	Cellular Component	Extracellular Region Cell Nucleus Cytoplasm Cytosol Intracellular Ferritin Complex Autolysosome Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Host Cell Extrinsic Component Of Postsynaptic Specialization Membrane Glutamatergic Synapse
	Molecular Function	Ferroxidase Activity Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding	RNA Binding Protein Binding Nuclear Localization Sequence Binding Histone Deacetylase Binding Nuclear Import Signal Receptor Activity
	Biological Process	Iron Ion Transport Cellular Iron Ion Homeostasis Intracellular Sequestering Of Iron Ion Immune Response Negative Regulation Of Cell Proliferation Neutrophil Degranulation Negative Regulation Of Fibroblast Proliferation Oxidation-reduction Process	Regulation Of DNA Recombination DNA Metabolic Process NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Process Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Viral Life Cycle
Pathways		Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport	CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression
Drugs		Iron Dextran Iron
Diseases
GWAS		Estradiol levels ( 22675492) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)	Feeling lonely ( 29500382) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Regular attendance at a religious group ( 29970889)
Interacting Genes		35 interacting genes: BRD7 CD99 CDC16 CDC25A CRMP1 CSF3R CSNK2B DAXX ELL3 FTL FXR2 GOLM1 GRB2 KPNA2 LBP MAX MYL3 NR1I3 NR3C1 NR5A2 NTAQ1 PACSIN1 PCBP1 PCBP2 PIAS4 SDCBP SIRPA SOX5 SPP1 STAT1 TICAM2 TOLLIP TRAF4 UBR1 YWHAE	105 interacting genes: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A BAG6 BRCA1 BTBD2 CASP2 CCDC107 CDA CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSE1L CSNK1A1 CUL4B DCTN2 DDIT3 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 GTF2IRD1 H1-0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MVP NECAB2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RAN RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SART3 SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131
Entrez ID		2495	3838
HPRD ID		00615	02818
Ensembl ID		ENSG00000167996	ENSG00000182481
Uniprot IDs		A0A024R525 P02794	P52292
PDB IDs		1FHA 2CEI 2CHI 2CIH 2CLU 2CN6 2CN7 2FHA 2IU2 2Z6M 3AJO 3AJP 3AJQ 3ERZ 3ES3 4DYX 4DYY 4DYZ 4DZ0 4OYN 4Y08 4YKH 4ZJK 5CMQ 5CMR 5GN8 5GOU 5JKK 5JKL 5JKM 5N26 5N27 5UP7 5UP8 5UP9 5VTD 5XB1 5YI5 5ZND 6B8F 6B8G 6FTV 6GSR 6H5I 6H6T 6H6U 6IPC 6IPO 6IPP 6IPQ 6J4A 6J7G 6KE2 6KE4	1EFX 1QGK 1QGR 3FEX 3FEY 3WPT 4E4V 4WV6 5H43
Enriched GO Terms of Interacting Partners?
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