ALPL and PCSK6

		ALPL	PCSK6
Description		alkaline phosphatase, biomineralization associated	proprotein convertase subtilisin/kexin type 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Extracellular Matrix Anchored Component Of Membrane Extracellular Membrane-bounded Organelle Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Alkaline Phosphatase Activity Protein Binding Pyrophosphatase Activity Metal Ion Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Nerve Growth Factor Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Developmental Process Involved In Reproduction Dephosphorylation Response To Lipopolysaccharide Response To Vitamin D Response To Antibiotic Response To Glucocorticoid Cellular Response To Organic Cyclic Compound Cementum Mineralization	Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Processing Nerve Growth Factor Production Secretion By Cell Regulation Of Lipoprotein Lipase Activity Cornification
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases		Hypophosphatasia
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) B6 vitamer levels (multivariate analysis) ( 30583557) Blood metabolite ratios ( 24816252) Folate pathway vitamin levels ( 19303062 19744961) Heel bone mineral density ( 30598549) Hematological and biochemical traits ( 20139978) Kidney stones ( 26272126 31729369) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Phosphorus levels ( 29403010 20558539) Plasma pyridoxal phosphate to pyridoxal ratio ( 31641590) Pyridoxal 5'-phosphate levels ( 25972531 31641590) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Serum alkaline phosphatase levels ( 31666285 29403010) Urinary metabolite levels in chronic kidney disease ( 31959995) Urolithiasis ( 30975718) Vitamin B levels in ischemic stroke ( 25147783)	Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Platelet-derived growth factor BB levels ( 27989323) Relative hand skill in reading disability ( 24068947) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)
Interacting Genes		7 interacting genes: ALOX5 EEF1A1 MAP3K14 PCSK6 SRPK2 TRAF2 TRAF3	10 interacting genes: ALPL CACNA1A FLG FN3K IGF1R IL16 PMCH RCN3 SNRPA1 SYNM
Entrez ID		249	5046
HPRD ID		01377	01329
Ensembl ID		ENSG00000162551	ENSG00000140479
Uniprot IDs		A0A024RAB4 P05186	A2RQD9 H7BXT3 P29122 Q59H04
PDB IDs
Enriched GO Terms of Interacting Partners?
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