LEMD3 and BCLAF1

Number of citations of the paper that reports this interaction (PubMedID 15681850)
50

Data Source:
HPRD (in vivo, in vitro)

		LEMD3	BCLAF1
Description		LEM domain containing 3	BCL2 associated transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Inner Membrane Integral Component Of Nuclear Inner Membrane Membrane Integral Component Of Membrane Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	DNA Binding Protein Binding	DNA Binding RNA Binding Protein Binding
	Biological Process	Angiogenesis Nucleus Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction	Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Transcription, DNA-templated Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of DNA-templated Transcription, Initiation Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerisation of the Nuclear Lamina
Drugs
Diseases		Disorders caused by loss-of-function of LEMD3, including: Osteopoikilosis; Buschke-Ollendorff syndrome (BOS); Melorheostosis
GWAS		Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Height ( 31562340) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		5 interacting genes: BCLAF1 SMAD1 SMAD2 SMAD3 SMAD9	10 interacting genes: BCL2 BCL2L1 CHD1 CLK1 CSNK2A1 EMD LEMD3 PIN1 SRPK2 YWHAG
Entrez ID		23592	9774
HPRD ID		09704	16544
Ensembl ID		ENSG00000174106	ENSG00000029363
Uniprot IDs		A0A024RBB9 Q9Y2U8	Q9NYF8
PDB IDs		2CH0 5ZOJ 5ZOK
Enriched GO Terms of Interacting Partners?
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