MAPK8IP2 and ASRGL1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		MAPK8IP2	ASRGL1
Description		mitogen-activated protein kinase 8 interacting protein 2	asparaginase and isoaspartyl peptidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Protein-containing Complex Neuronal Cell Body	Photoreceptor Inner Segment Nucleus Cytoplasm Cytosol
	Molecular Function	Amyloid-beta Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding Kinesin Binding Protein Kinase Binding Protein-containing Complex Binding	N4-(beta-N-acetylglucosaminyl)-L-asparaginase Activity Asparaginase Activity Beta-aspartyl-peptidase Activity
	Biological Process	Behavioral Fear Response Receptor-mediated Endocytosis Signal Complex Assembly JNK Cascade Mating Behavior Regulation Of Signaling Receptor Activity Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Positive Regulation Of Endocytosis Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity Negative Regulation Of Apoptotic Signaling Pathway	Proteolysis L-phenylalanine Catabolic Process Asparagine Catabolic Process Via L-aspartate
Pathways			Phenylalanine metabolism
Drugs			L-Aspartic Acid L-Asparagine
Diseases
GWAS		Hip circumference ( 28552196)	Body fat mass ( 28552196) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Heel bone mineral density ( 30598549) Trunk fat mass ( 28552196) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		84 interacting genes: ADRB2 AFG3L2 ANAPC10 APP ASRGL1 BBS10 C1QTNF3 C22orf39 C8orf33 CFL1 CHN1 CRMP1 CRP CTNNBL1 DUSP16 DUSP18 EGFR ERBB2 ERG28 EZH2 FGF12 FGF13 FSCN1 GALNT3 GBP2 HLA-C IGIP ING4 ITSN1 KIFC2 KLC1 LEFTY2 LRP1 LRP2 LRP8 LSM8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 MNDA MRE11 MSRB3 NDUFS6 NUMB PLXNA3 PRSS23 RAI1 RBM4 RBX1 RPS6KB2 RYBP SCLT1 SH2D1B SLC39A13 SLPI SMARCB1 SMS SPINK2 SPSB3 SRP19 SYNE2 TARBP2 TIAM1 TMEM128 TP53BP2 UNC119 USP46 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF670 ZNF784 ZNRD1	4 interacting genes: GSK3B MAP2K5 MAPK8IP2 TAB1
Entrez ID		23542	80150
HPRD ID		09674	07006
Ensembl ID		ENSG00000008735	ENSG00000162174
Uniprot IDs		Q13387	A0A024R573 Q7L266
PDB IDs			3TKJ 4ET0 4O0C 4O0D 4O0E 4O0F 4O0G 4O0H 4OSX 4OSY 4PVP 4PVQ 4PVR 4PVS 4ZM9
Enriched GO Terms of Interacting Partners?
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