FOS and RUNX1

Number of citations of the paper that reports this interaction (PubMedID 11641401)
50

Data Source:
HPRD (in vivo)

		FOS	RUNX1
Description		Fos proto-oncogene, AP-1 transcription factor subunit	RUNX family transcription factor 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Cytosol Membrane Protein-DNA Complex Transcription Factor AP-1 Complex Neuron Projection	Nuclear Chromatin Nucleus Nucleoplasm Core-binding Factor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein-containing Complex Binding R-SMAD Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding ATP Binding Transcription Regulatory Region DNA Binding
	Biological Process	Conditioned Taste Aversion DNA Methylation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Female Pregnancy Aging Response To Cold Response To Light Stimulus Response To Gravity Response To Toxic Substance Cytokine-mediated Signaling Pathway Sleep Cellular Response To Extracellular Stimulus Response To Lipopolysaccharide Response To Progesterone Cellular Response To Hormone Stimulus Cellular Response To Reactive Oxygen Species Response To Immobilization Stress Skeletal Muscle Cell Differentiation Response To Muscle Stretch Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-binding Transcription Factor Activity Response To Corticosterone Response To CAMP SMAD Protein Signal Transduction Cellular Response To Cadmium Ion Cellular Response To Calcium Ion Positive Regulation Of Neuron Death Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Ossification Regulation Of Cytokine-mediated Signaling Pathway Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Hemopoiesis Regulation Of Wnt Signaling Pathway Neuron Differentiation Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Interleukin-2 Production Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Regulatory T Cell Differentiation Regulation Of Cell Differentiation Regulation Of Keratinocyte Differentiation Regulation Of Myeloid Cell Differentiation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Neuron Development Regulation Of B Cell Receptor Signaling Pathway Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Bicellular Tight Junction Assembly
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes Estrogen-dependent gene expression NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Pre-NOTCH Transcription and Translation Organic cation transport RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates estrogen receptor mediated transcription Regulation of RUNX1 Expression and Activity Regulation of RUNX1 Expression and Activity RUNX1 regulates expression of components of tight junctions RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 regulates transcription of genes involved in WNT signaling RUNX2 regulates genes involved in differentiation of myeloid cells RUNX3 regulates p14-ARF Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis
Drugs		Pseudoephedrine Nadroparin
Diseases			Chronic myeloid leukemia (CML) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Acute myeloid leukemia (AML) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Periodontal microbiota ( 22699663)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 30929738 31619474) Asthma (adult onset) ( 31036433 30929738) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Breast cancer ( 31757997) Celiac disease and Rheumatoid arthritis ( 26546613) Core binding factor acute myeloid leukemia ( 27903959) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Esophageal cancer ( 21642993) Esophageal squamous cell carcinoma ( 25129146) Femoral neck length ( 30888730) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) Immune response to smallpox vaccine (IL-6) ( 22542470) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Male-pattern baldness ( 29146897 27182965 28196072) Medication use (adrenergics, inhalants) ( 31015401) Neutrophil percentage of granulocytes ( 27863252) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Platelet count ( 27863252) Plateletcrit ( 27863252) Preeclampsia ( 23551011) Psoriasis ( 25903422) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		114 interacting genes: ANP32E APP AQP1 ARFGAP1 ARL6IP4 ATF2 ATF3 ATF4 ATF7 ATP5ME BATF BCL3 CABP1 CARM1 CCND1 CEBPA CEBPE CEBPG CENPO CFAP57 CLU COPS4 CREB5 CREBBP CSNK2A1 CSNK2A2 CYTH4 DDIT3 DNMT3L EEF1D ELK1 ELK4 EPHB2 ETS1 ETS2 FHL3 GAMT GATA4 GLB1 GNG11 GRHPR GTF2E2 GTF2F1 GTF2F2 HNF1A HSPA1A JUN JUNB JUND KDM2A KDM2B LMNA LMO3 LUZP4 MAF MAFB MAFF MAP1B MAP3K7 MAPK1 MAPK3 MAPK7 MITF MTERF4 NACA NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEFM NELFB NFATC3 NFKB1 OPTN PIN1 PML POLR2E PRKAA2 PRKACA PSMC5 RB1 RELA RPS6KA1 RPS6KA2 RPS6KA4 RUNX1 RUNX2 SCHIP1 SET SIRT1 SMAD3 SMARCD1 SPI1 SRA1 STAT1 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TBP TRO TSC22D3 TSPAN2 UBE2D1 UBE2I UBE2L3 UBR1 USF1 USF2 VDR XBP1 ZNF133	54 interacting genes: AR CBFA2T2 CBFA2T3 CBFB CCND1 CCND2 CCND3 CDK1 CDK6 CEBPA CEBPB COL6A1 COPRS CTBP2 DNMT1 DTX2 DZIP3 ELF1 ELF2 ELF4 EP300 FOS FOXP3 HIPK1 HIPK2 IKZF1 IKZF3 JUN KAT6A KAT6B MYOD1 NCOR1 NCOR2 NEDD4 PAX5 PRMT1 RBM14 RNF38 RNF44 SPEN SPI1 SUV39H1 TAZ TLE1 TLE2 TLE5 TRIM5 UBE2L6 UHRF2 UXT VDR WWP1 WWTR1 YAP1
Entrez ID		2353	861
HPRD ID		01275	01043
Ensembl ID		ENSG00000170345	ENSG00000159216
Uniprot IDs		P01100 Q6FG41	Q01196
PDB IDs		1A02 1FOS 1S9K	1CMO 1CO1 1E50 1H9D 1LJM
Enriched GO Terms of Interacting Partners?
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