FOLR1 and IRAK3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		FOLR1	IRAK3
Description		folate receptor alpha	interleukin 1 receptor associated kinase 3
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Endosome Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Clathrin-coated Vesicle Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Folic Acid Binding Drug Binding Signaling Receptor Activity Methotrexate Binding Folic Acid Receptor Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Heart Looping Neural Crest Cell Migration Involved In Heart Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis ER To Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Folic Acid Transport Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Folic Acid Metabolic Process COPII Vesicle Coating Regulation Of Canonical Wnt Signaling Pathway Pharyngeal Arch Artery Morphogenesis Anterior Neural Tube Closure Cellular Response To Folic Acid Folate Import Across Plasma Membrane	Negative Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Complex Disassembly Regulation Of Protein Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling
Drugs		Folic Acid Vintafolide Farletuzumab
Diseases
GWAS			Smooth-surface caries ( 24556642) White blood cell count (basophil) ( 29403010)
Interacting Genes		5 interacting genes: CUL3 INTS4 IRAK3 LYN NCAPH2	17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6
Entrez ID		2348	11213
HPRD ID		00638	05123
Ensembl ID		ENSG00000110195	ENSG00000090376
Uniprot IDs		A0A024R5H1 P15328	Q9Y616
PDB IDs		4KM6 4KM7 4KMX 4LRH 5IZQ	5UKE
Enriched GO Terms of Interacting Partners?
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