RYBP and RNF8

Number of citations of the paper that reports this interaction (PubMedID 29320735)
3

Data Source:
BioGRID (enzymatic study)

		RYBP	RNF8
Description		RING1 and YY1 binding protein	ring finger protein 8
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm PcG Protein Complex	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Midbody Site Of Double-strand Break
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Metal Ion Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Multicellular Organism Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Cycle Spermatid Development Response To Ionizing Radiation Viral Process Protein Ubiquitination Histone H2A Ubiquitination Histone H2B Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Spermatogenesis, Exchange Of Chromosomal Proteins Interstrand Cross-link Repair Histone Exchange Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Height ( 28552196 20881960 25282103 25429064 23563607 31562340) Medication use (beta blocking agents) ( 31015401) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Resting-state electroencephalogram vigilance ( 29703947) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 25673412 28448500)	Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)
Interacting Genes		28 interacting genes: ABL1 CASP10 CASP8 CBX2 CRK E2F2 E2F3 E2F4 E2F6 FADD FANK1 FHL3 GABPB1 GABPB2 HSPB1 MAPK8IP2 MDM2 NMI NOS1AP RBBP4 RING1 RNF2 RNF8 SOCS2 UBC UBE3A YY1 ZFP42	41 interacting genes: BLM CCDC85B CEP44 CHD4 CHEK2 EXOSC2 H2AC20 H2AX H2BC21 H2BC3 H3-3B HOMEZ JMJD1C KDM4A MAD1L1 MAGED1 MDC1 MDM2 PCNA PNMA2 POLD4 RBFOX2 RXRA RYBP SEPTIN3 SUMO2 SUMO3 TMEM79 TRIM29 UBC UBE2D1 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL YEATS4
Entrez ID		23429	9025
HPRD ID		09607	11521
Ensembl ID		ENSG00000163602	ENSG00000112130
Uniprot IDs		Q8N488	O76064
PDB IDs		3IXS	2CSW 2PIE 4AYC 4ORH 4WHV
Enriched GO Terms of Interacting Partners?
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