Wiki-CORONA
About
Search
Browse
Data Sources
People
Funding
Advanced Search
FN1 and ITGA5
Number of citations of the paper that reports this interaction (PubMedID
9211865
)
52
Data Source:
HPRD
(in vivo, in vitro)
FN1
ITGA5
Description
fibronectin 1
integrin subunit alpha 5
Image
GO Annotations
Cellular Component
Extracellular Region
Fibrinogen Complex
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment
Apical Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Ruffle
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Cytoplasmic Vesicle
Ruffle Membrane
Integrin Alpha5-beta1 Complex
Synapse
Alphav-beta3 Integrin-vitronectin Complex
Molecular Function
Protease Binding
Signaling Receptor Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Protein Binding
Collagen Binding
Protein C-terminus Binding
Heparin Binding
Peptidase Activator Activity
Enzyme Binding
Identical Protein Binding
Proteoglycan Binding
Chaperone Binding
Disordered Domain Specific Binding
Virus Receptor Activity
Epidermal Growth Factor Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
Vascular Endothelial Growth Factor Receptor 2 Binding
Metal Ion Binding
Biological Process
Angiogenesis
Regulation Of Protein Phosphorylation
Platelet Degranulation
Acute-phase Response
Cell-substrate Junction Assembly
Cell Adhesion
Calcium-independent Cell-matrix Adhesion
Positive Regulation Of Cell Proliferation
Regulation Of Cell Shape
Response To Wounding
Positive Regulation Of Gene Expression
Positive Regulation Of Peptidase Activity
Peptide Cross-linking
Cytokine-mediated Signaling Pathway
Extracellular Matrix Organization
Integrin Activation
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Wound Healing
Post-translational Protein Modification
Cellular Protein Metabolic Process
Positive Regulation Of Axon Extension
Positive Regulation Of Fibroblast Proliferation
Leukocyte Migration
Interaction With Symbiont
Regulation Of ERK1 And ERK2 Cascade
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Negative Regulation Of Transforming Growth Factor-beta Secretion
Angiogenesis
Cell-substrate Junction Assembly
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Integrin-mediated Signaling Pathway
Female Pregnancy
Memory
Positive Regulation Of Cell-substrate Adhesion
CD40 Signaling Pathway
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Wound Healing, Spreading Of Epidermal Cells
Endodermal Cell Differentiation
Viral Entry Into Host Cell
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Positive Regulation Of Sprouting Angiogenesis
Negative Regulation Of Anoikis
Pathways
Platelet degranulation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Extracellular matrix organization
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Interleukin-4 and Interleukin-13 signaling
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates PTK2 signaling
Post-translational protein phosphorylation
Signaling downstream of RAS mutants
Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Signal transduction by L1
RUNX2 regulates genes involved in cell migration
Drugs
Zinc
Ocriplasmin
Resveratrol
Diseases
GWAS
Blood protein levels (
30072576
28240269
)
Cholesterol, total (
26780889
)
Coronary artery disease (
29212778
28714974
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Diastolic blood pressure (
30578418
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
28334899
)
Negative urgency (
30718321
)
Pulse pressure (
28135244
27841878
30578418
)
Systolic blood pressure (
27841878
30578418
)
Total cholesterol levels (
28334899
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
103 interacting genes:
ADAMTS4
AMBP
ANOS1
APCS
ATXN10
ATXN7
C1QA
CCN3
CD44
CDKN2A
COL13A1
COL1A1
COL1A2
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL6A2
COL7A1
COMP
CRP
CTSD
CXCL12
DCN
DUSP10
EGFR
F13A1
FAM86B3P
FASLG
FBLN1
FBLN2
FST
FSTL3
GALNT6
GRB2
GSN
HGF
HRG
HSPG2
IGFBP3
IGFBP5
ITGA2B
ITGA3
ITGA4
ITGA5
ITGA8
ITGB1
ITGB3
ITGB6
ITGB7
KLK3
KPNA2
LACRT
LGALS3BP
LPA
LRG1
LTBP1
MAG
MATN2
MEP1A
MEP1B
MIA
MMP9
MTDH
MTNR1A
MYOC
NPTX1
NR0B2
NT5E
PELI2
PKD1
PLAT
PLG
PRELP
PRPF40A
RARA
RBL1
REG3A
RPS6KA5
SCGB1A1
SDC2
SKIL
SMAD4
SMAD9
SPARC
STAT5A
TAB1
TAB2
TAC1
TGFBI
TGM2
THBS1
TIMD4
TMPRSS6
TNC
TNFRSF11B
TSHR
UBQLN1
VEGFA
VHL
31 interacting genes:
ANGPT1
ANGPT2
ANGPTL3
ARHGAP5
AUP1
CD9
CHMP2A
CLK1
COL18A1
COL1A1
EGFR
ERBB2
FGFR2
FLT4
FN1
GIPC1
GRK6
ITGB1
ITGB3
ITGB5
L1CAM
LGALS3BP
NISCH
PECAM1
RABIF
SHARPIN
SPP1
STAMBP
TNC
UBAP1
VCL
Entrez ID
2335
3678
HPRD ID
00626
00627
Ensembl ID
ENSG00000115414
ENSG00000161638
Uniprot IDs
B7ZLE5
P02751
Q6MZF4
Q6MZM7
Q6N084
Q9UQS6
B2R627
P08648
PDB IDs
1E88
1E8B
1FBR
1FNA
1FNF
1FNH
1J8K
1O9A
1OWW
1Q38
1QGB
1QO6
1TTF
1TTG
2CG6
2CG7
2CK2
2CKU
2EC3
2FN2
2FNB
2GEE
2H41
2H45
2HA1
2MNU
2N1K
2OCF
2RKY
2RKZ
2RL0
3CAL
3EJH
3GXE
3M7P
3MQL
3R8Q
3T1W
3ZRZ
4GH7
4JE4
4JEG
4LXO
4MMX
4MMY
4MMZ
4PZ5
5DC0
5DC4
5DC9
5DFT
5J6Z
5J7C
5M0A
5N47
5N48
6HNF
6MFA
6MSV
3VI3
3VI4
4WJK
4WK0
4WK2
4WK4
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?