UBR2 and UBE2B

Number of citations of the paper that reports this interaction (PubMedID 14585983)
59

Data Source:
HPRD (in vivo)

		UBR2	UBE2B
Description		ubiquitin protein ligase E3 component n-recognin 2	ubiquitin conjugating enzyme E2 B
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleus Cytoplasm Cytosol	Chromatin Nuclear Chromatin XY Body Cell Nucleus Nucleoplasm Replication Fork Cytoplasm Plasma Membrane HULC Complex
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Chromatin Silencing Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Negative Regulation Of Transposition Protein Ubiquitination Negative Regulation Of TOR Signaling Histone H2A Ubiquitination Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Protein Polyubiquitination In Utero Embryonic Development DNA Repair Postreplication Repair Maintenance Of Chromatin Silencing Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Spermatogenesis Sperm Axoneme Assembly Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Histone Ubiquitination Negative Regulation Of Histone Phosphorylation Histone H2A Ubiquitination Response To Drug DNA Damage Response, Detection Of DNA Damage Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of CAMP-mediated Signaling Meiotic Telomere Clustering Protein Stabilization Chiasma Assembly Protein Autoubiquitination Histone Lysine Demethylation Synaptonemal Complex Organization Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Recognition of DNA damage by PCNA-containing replication complex Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Lung cancer in never smokers ( 28604730) Obesity-related traits ( 23251661) Serum total protein level ( 29403010)	Relative amplitude of rest-activity cycles ( 30120083)
Interacting Genes		5 interacting genes: H2AC20 H2BC8 UBE2B UBE2D2 UBE2H	25 interacting genes: BIRC2 CBX5 CDKN1B CNOT4 CRMP1 CTNNB1 FBN2 H2AC20 MED31 PCNA PRKN RAD18 RC3H1 RC3H2 RNF20 RNF4 RNF40 TRIM14 TRIM45 UBA1 UBR1 UBR2 UBR3 UBR5 UNC119
Entrez ID		23304	7320
HPRD ID		09853	01533
Ensembl ID		ENSG00000024048	ENSG00000119048
Uniprot IDs		B3KXG6 Q8IWV8	P63146
PDB IDs		3NY2 3NY3 5TDA 5TDB 5TDD 5UM3	1JAS 1NXA 2Y4W 2YB6 2YBF
Enriched GO Terms of Interacting Partners?
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