FBXW11 and CSNK1E

Number of citations of the paper that reports this interaction (PubMedID 23555304)
16

Data Source:
BioGRID (two hybrid)

		FBXW11	CSNK1E
Description		F-box and WD repeat domain containing 11	casein kinase 1 epsilon
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Centrosome Cytosol SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Viral Process Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling	G2/M Transition Of Mitotic Cell Cycle DNA Repair Protein Phosphorylation Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Wnt Signaling Pathway Peptidyl-serine Phosphorylation Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Canonical Wnt Signaling Pathway Ciliary Basal Body-plasma Membrane Docking Regulation Of Cellular Protein Localization Positive Regulation Of Wnt-mediated Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Non-canonical Wnt Signaling Pathway
Pathways		Activation of NF-kappaB in B cells Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling NIK - noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Antigen processing: Ubiquitination & Proteasome degradation	WNT mediated activation of DVL Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Circadian Clock Anchoring of the basal body to the plasma membrane Major pathway of rRNA processing in the nucleolus and cytosol AURKA Activation by TPX2
Drugs
Diseases
GWAS		Height ( 28552196 20881960 25282103 25429064 23563607 31562340) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Keratoconus ( 31855235)
Interacting Genes		23 interacting genes: BHLHE41 BTRC CDC25A CSNK1E CUL1 DAPK1 GLI2 GSK3B IFNAR1 KDR MCL1 NFKB1 NFKBIA PPP1CC PPP2R1B PPP2R5E PRKACA PRLR TBC1D4 TRIM21 UBE2D3 WEE1 ZNF281	53 interacting genes: AKAP9 ANKRD6 APC APP ARHGEF1 ARNTL AXIN1 AXIN2 BBS10 BHLHE41 BID CADM4 CLOCK CRY1 CSNK2B DELEC1 DVL1 DVL2 DVL3 ENTR1 FAM110A FAM110C FAM83D FBP1 FBXO7 FBXW11 GTF3C1 HES1 KAT7 MCC NCOA3 NR1D2 PER1 PER2 PER3 PPP1CA PPP1CC PPP1R14A PPP2R5D PPP2R5E PTPRD RAD54B RBX1 RORA RORC SOCS3 TAOK1 TAZ TNS2 TRAF3 WDCP ZMYND8 ZNF227
Entrez ID		23291	1454
HPRD ID		07294	02919
Ensembl ID		ENSG00000072803	ENSG00000213923
Uniprot IDs		B4DH70 Q9UKB1	P49674 Q5U045
PDB IDs			4HNI 4HOK
Enriched GO Terms of Interacting Partners?
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