ARL6IP1 and SENP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ARL6IP1	SENP2
Description		ADP ribosylation factor like GTPase 6 interacting protein 1	SUMO specific peptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane	Nucleus Nuclear Pore Nucleoplasm Cytosol PML Body Nuclear Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding SUMO-specific Protease Activity Protein Domain Specific Binding SUMO-specific Endopeptidase Activity SUMO-specific Isopeptidase Activity
	Biological Process	Positive Regulation Of L-glutamate Import Across Plasma Membrane Cotranslational Protein Targeting To Membrane Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Endoplasmic Reticulum Tubular Network Formation Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Membrane Organization	Positive Regulation Of Protein Phosphorylation Heart Development Dorsal/ventral Axis Specification Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Negative Regulation Of Protein Binding Regulation Of DNA Endoreduplication Negative Regulation Of Chromatin Binding Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Spongiotrophoblast Layer Development Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			SUMO is proteolytically processed
Drugs
Diseases
GWAS			Diastolic blood pressure ( 28135244 27841878) Estimated glomerular filtration rate ( 31152163 31015462) Height ( 28552196) Hip circumference ( 28552196) PR interval ( 30046033) QRS duration ( 30012220) Seborrheic dermatitis ( 29203360) Systolic blood pressure ( 27841878 26969751)
Interacting Genes		41 interacting genes: ACSF2 ARL4D ARL6 CERT1 DIABLO FBXW7 FDFT1 FXR2 GAD2 GOLPH3 GOLPH3L GORASP2 HGS HMGCL INPP5K LMNA MTERF3 MYG1 NAPB NDRG4 NUDT3 PAM16 PBX3 RAB33A RETREG3 SENP2 SHMT2 SNX1 SNX10 SNX11 SNX12 SNX15 SNX3 SNX4 SPG21 SUCLA2 TFAM TUFM WIPI2 ZFYVE21 ZNF391	28 interacting genes: AGTRAP APP ARL6IP1 AXIN1 CDCA5 CDK5RAP2 DAXX FUNDC1 FZR1 IKBKG KASH5 KPNA1 KPNB1 LMNA MYC NACC1 NEDD4L NUP153 PML RANGAP1 STK38 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TPD52 TRIM63
Entrez ID		23204	59343
HPRD ID		09641	07002
Ensembl ID		ENSG00000170540	ENSG00000163904
Uniprot IDs		A0A024QYV7 Q15041	Q9HC62
PDB IDs			1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5 5AEK
Enriched GO Terms of Interacting Partners?
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