CYFIP1 and MYO16

Number of citations of the paper that reports this interaction (PubMedID 21946561)
15

Data Source:
BioGRID (pull down)

		CYFIP1	MYO16
Description		cytoplasmic FMR1 interacting protein 1	myosin XVI
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Region Cytosol MRNA Cap Binding Complex Focal Adhesion Lamellipodium SCAR Complex Filopodium Tip Secretory Granule Lumen Specific Granule Lumen Neuron Projection Neuronal Cell Body Terminal Bouton Dendritic Spine Dendritic Growth Cone Axonal Growth Cone Synapse Perinuclear Region Of Cytoplasm Excitatory Synapse Extracellular Exosome Central Region Of Growth Cone Peripheral Region Of Growth Cone Tertiary Granule Lumen	Nucleoplasm Cytoplasm Plasma Membrane Myosin Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA 7-methylguanosine Cap Binding Protein Binding Translation Regulator Activity Rac GTPase Binding Actin Filament Binding	Motor Activity Protein Binding ATP Binding Actin Filament Binding
	Biological Process	Cell Morphogenesis Regulation Of Translation Axon Guidance Regulation Of Cell Shape Rac Protein Signal Transduction Cell Projection Assembly Lamellipodium Assembly Ruffle Organization Cellular Response To Insulin Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neutrophil Degranulation Positive Regulation Of Axon Extension Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Extension Cognition Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Response To Electrical Stimulus Dendrite Extension Modification Of Synaptic Structure Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Positive Regulation Of Dendrite Development Positive Regulation Of Ruffle Assembly Negative Regulation Of Synaptic Vesicle Recycling Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Negative Regulation Of Cell Proliferation Cerebellum Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Triglyceride levels x loop diuretics use interaction ( 31806883)	Alzheimer's disease ( 30636644) Alzheimer's disease (cognitive decline) ( 23535033) Blood pressure ( 22763476) Chronotype ( 30696823) Colorectal cancer ( 29228715) Dental caries ( 23064961) Lung function (FEV1/FVC) ( 30804560) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Monocyte count ( 27863252) Nose size ( 27182965) Obesity-related traits ( 23251661) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Presence of antiphospholipid antibodies ( 23509613) Red blood cell count ( 27863252) Resting-state electroencephalogram vigilance ( 29703947) Seasonality ( 25562672) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		19 interacting genes: ACTA1 APBB1 EFHC2 EFTUD2 FMR1 FXR2 GAS7 GNB1 MEOX1 MYO16 NUP98 NYAP1 NYAP2 PPP1CC PRPF40A RAC1 RFX6 SCTR TCERG1	6 interacting genes: CYFIP1 NCKAP1 NRXN1 PIK3R1 PPP1CA PPP1CC
Entrez ID		23191	23026
HPRD ID		05890	14795
Ensembl ID		ENSG00000273749	ENSG00000041515
Uniprot IDs		Q7L576	F8W883 Q9Y6X6
PDB IDs		3P8C 4N78
Enriched GO Terms of Interacting Partners?
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