RRP1B and PPP1CC

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, proximity labelling technology, affinity chromatography technology, two hybrid)

		RRP1B	PPP1CC
Description		ribosomal RNA processing 1B	protein phosphatase 1 catalytic subunit gamma
Image		No pdb structure
GO Annotations	Cellular Component	Euchromatin Heterochromatin Granular Component Nucleus Nucleoplasm Nucleolus Cytosol Preribosome, Large Subunit Precursor Preribosome, Small Subunit Precursor	Protein Phosphatase Type 1 Complex Condensed Chromosome Kinetochore Nuclear Chromosome, Telomeric Region Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein-containing Complex Dendritic Spine PTW/PP1 Phosphatase Complex Presynapse Glutamatergic Synapse
	Molecular Function	Transcription Coactivator Activity RNA Binding Protein Binding	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Lamin Binding Protein C-terminus Binding Protein Phosphatase 1 Binding Phosphatase Activity Protein Kinase Binding Protein Domain Specific Binding Protein-containing Complex Binding Metal Ion Binding Protein N-terminus Binding
	Biological Process	RRNA Processing MRNA Processing Apoptotic Process RNA Splicing Negative Regulation Of Phosphatase Activity Viral Process Negative Regulation Of GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of RNA Splicing Positive Regulation By Host Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Virus	Glycogen Metabolic Process Protein Dephosphorylation Cell Cycle Neuron Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Nucleocytoplasmic Transport Cell Division Positive Regulation Of Glial Cell Proliferation
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Triglyceride catabolism Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Circadian Clock RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs			9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A Motuporin
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Diastolic blood pressure ( 28135244 27618447) Mean corpuscular hemoglobin ( 27863252) Systolic blood pressure ( 27618447)	Heart rate ( 23583979)
Interacting Genes		4 interacting genes: CSNK2A1 LSM1 PPP1CC SRPK2	121 interacting genes: AATK ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C1QA C9orf50 CEP126 CLMN CLOCK CLTC CNST COPS5 CSNK1A1 CSNK1E CSNK2B CSRNP1 CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DELEC1 DYRK4 EIF2AK2 ELP4 ENKD1 FBXW11 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IFTAP IL3RA INSYN1 JAK2 KCTD20 KDM4D KRCC1 LMTK2 MAP4K4 MAPT MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R2B PPP1R32 PPP1R35 PPP1R3D PPP1R8 PPP1R9B PPP2R5C PRR16 RAF1 RB1 RIF1 RNF19B RORC RPL7 RPRD2 RRM1 RRP1B SDR39U1 SFRP1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 STAU1 TACC2 TBC1D19 TCTEX1D4 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A TWISTNB VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF667
Entrez ID		23076	5501
HPRD ID		10009	08911
Ensembl ID		ENSG00000160208	ENSG00000186298
Uniprot IDs		Q14684	A0A024RBP2 P36873
PDB IDs			1IT6 1JK7 1U32 2BCD 2BDX 4UT2 4UT3 5INB 5J28
Enriched GO Terms of Interacting Partners?
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