WAPL and ARAP1

Number of citations of the paper that reports this interaction (PubMedID 21275903)
8

Data Source:
BioGRID (two hybrid)

		WAPL	ARAP1
Description		WAPL cohesin release factor	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Synaptonemal Complex Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Type 1 Angiotensin Receptor Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Negative Regulation Of DNA Replication Response To Toxic Substance Viral Process Negative Regulation Of Chromatin Binding Meiotic Chromosome Segregation Negative Regulation Of Sister Chromatid Cohesion Positive Regulation Of Fibroblast Proliferation Cell Division Regulation Of Chromosome Condensation Protein Localization To Chromatin Regulation Of Cohesin Loading	Positive Regulation Of Receptor Recycling Signal Transduction Regulation Of Cell Shape Actin Filament Reorganization Involved In Cell Cycle Positive Regulation Of GTPase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly
Pathways		Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion	Rho GTPase cycle PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Drugs
Diseases
GWAS		Parental longevity (father's age at death) ( 31484785)	Acute insulin response ( 28490609) Alcohol dependence symptom count ( 29460428) Alloimmunization response to red blood cell transfusion in sickle cell anemia ( 25670933) Body mass index ( 28892062 25673413) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Glycated hemoglobin levels ( 28898252) Household income (MTAG) ( 31844048) Mean platelet volume ( 27863252) Medication use (drugs used in diabetes) ( 31015401) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963) Type 2 diabetes ( 22885922 24509480 30054458 26961502 29358691 30297969 26818947 30718926 28869590) Waist circumference ( 28552196) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		4 interacting genes: ARAP1 MTNR1A RAD21 XRN1	12 interacting genes: APP ARIH2 ARPC3 FGFR3 INPP5D KCTD12 PSD3 TAB1 TES TP53BP1 WAPL XRCC6
Entrez ID		23063	116985
HPRD ID		11072	09440
Ensembl ID		ENSG00000062650	ENSG00000186635
Uniprot IDs		A8K273 B2RTX8 Q7Z5K2	Q96P48
PDB IDs		4K6J 5HDT	4X1V
Enriched GO Terms of Interacting Partners?
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