FOXC1 and TOMM70

		FOXC1	TOMM70
Description		forkhead box C1	translocase of outer mitochondrial membrane 70
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nuclear Heterochromatin Cytosol	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Promoter-specific Chromatin Binding	Protein Binding Protein Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Ovarian Follicle Development Eye Development Ureteric Bud Development In Utero Embryonic Development Somitogenesis Kidney Development Lymph Vessel Development Endochondral Ossification Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Heart Development Cell Proliferation Germ Cell Migration Anatomical Structure Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Mesenchymal Cell Development Neural Crest Cell Development Cell Migration Negative Regulation Of Angiogenesis Cerebellum Development Cell Differentiation Collagen Fibril Organization Glycosaminoglycan Metabolic Process Lacrimal Gland Development Embryonic Heart Tube Development Maintenance Of Lens Transparency Vascular Endothelial Growth Factor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Camera-type Eye Development Positive Regulation Of DNA Binding Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Organ Growth Vascular Endothelial Growth Factor Receptor Signaling Pathway Paraxial Mesoderm Formation Artery Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Chemokine-mediated Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Glomerular Epithelium Development Regulation Of Blood Vessel Diameter Negative Regulation Of Lymphangiogenesis Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Positive Regulation Of Core Promoter Binding Cellular Response To Chemokine	Protein Targeting To Mitochondrion Macroautophagy Protein Transmembrane Transport
Pathways			Mitochondrial protein import Pink/Parkin Mediated Mitophagy Ub-specific processing proteases
Drugs
Diseases		Axenfeld-Rieger syndrome (ARS)
GWAS		Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 26752265) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 26752265 29891935) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010 31959993 30054594) Monobrow thickness ( 26926045) Non-response to citalopram or escitalopram and depression ( 27622933) Response to platinum-based agents ( 22020760) Systolic blood pressure ( 30224653)
Interacting Genes		2 interacting genes: HMGB1 TOMM70	15 interacting genes: CTNNA2 DCBLD2 FOXC1 HSP90AA1 HSPA1A HSPB1 IRF3 KIF2C NIT2 OR5K4 PRKN PSAP TBC1D23 TFG TMEM45A
Entrez ID		2296	9868
HPRD ID		03054	16194
Ensembl ID		ENSG00000054598	ENSG00000154174
Uniprot IDs		Q12948 W6CJ52	O94826
PDB IDs
Enriched GO Terms of Interacting Partners?
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