FGF5 and PTX3

Number of citations of the paper that reports this interaction (PubMedID 25912421)
6

Data Source:
BioGRID (pull down)

		FGF5	PTX3
Description		fibroblast growth factor 5	pentraxin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Fibroblast Growth Factor Receptor Binding Growth Factor Activity	Complement Component C1q Binding (1->3)-beta-D-glucan Binding Protein Binding Identical Protein Binding Virion Binding
	Biological Process	MAPK Cascade Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Glial Cell Differentiation Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling	Ovarian Cumulus Expansion Response To Yeast Inflammatory Response Opsonization Extracellular Matrix Organization Neutrophil Degranulation Negative Regulation By Host Of Viral Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Phagocytosis Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Blond vs. brown/black hair color ( 30531825) Blood pressure ( 24954895 21909110) Blood urea nitrogen levels ( 31152163 29403010) Chronic kidney disease ( 31152163) Coronary artery disease ( 29212778 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Creatinine levels ( 29403010) Diastolic blood pressure ( 26390057 27736895 28135244 19430483 27841878 21909115 29403010 28739976 27618447 27618452 25249183 30487518 28871152) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010) Hypertension ( 25249183 30487518) Male-pattern baldness ( 29146897 27182965 28196072) Mean arterial pressure ( 26390057 29403010 30487518 28871152) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monobrow ( 27182965) Potassium levels ( 29403010) Pulse pressure ( 27841878 29403010 28739976 30487518 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Red blood cell count ( 29403010) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Serum uric acid levels ( 30993211 29403010) Systolic blood pressure ( 26390057 27736895 28135244 27841878 21909115 29403010 28739976 27618452 25249183 30487518 28871152 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urate levels ( 31578528 23263486)	Body mass index ( 26426971)
Interacting Genes		5 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 PTX3	15 interacting genes: C1QA C1QB C1QC CFH FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF5 FGF7 FGF8 MTNR1A
Entrez ID		2250	5806
HPRD ID		01307	03928
Ensembl ID		ENSG00000138675	ENSG00000163661
Uniprot IDs		P12034 Q8NBG6	P26022
PDB IDs
Enriched GO Terms of Interacting Partners?
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