FASN and PRR12

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		FASN	PRR12
Description		fatty acid synthase	proline rich 12
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Membrane Melanosome Glycogen Granule Extracellular Exosome	Nucleus Postsynaptic Density Cell Junction Neuron Projection
	Molecular Function	RNA Binding [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity 3-oxoacyl-[acyl-carrier-protein] Synthase Activity 3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity 3-hydroxypalmitoyl-[acyl-carrier-protein] Dehydratase Activity Oleoyl-[acyl-carrier-protein] Hydrolase Activity Protein Binding Drug Binding (3R)-hydroxymyristoyl-[acyl-carrier-protein] Dehydratase Activity 3-hydroxydecanoyl-[acyl-carrier-protein] Dehydratase Activity Myristoyl-[acyl-carrier-protein] Hydrolase Activity Palmitoyl-[acyl-carrier-protein] Hydrolase Activity Phosphopantetheine Binding Identical Protein Binding Cadherin Binding Enoyl-[acyl-carrier-protein] Reductase (NADPH, A-specific) Activity 3-hydroxyoctanoyl-[acyl-carrier-protein] Dehydratase Activity NADPH Binding 3-oxo-glutaryl-[acp] Methyl Ester Reductase Activity 3-oxo-pimeloyl-[acp] Methyl Ester Reductase Activity
	Biological Process	Osteoblast Differentiation Glandular Epithelial Cell Development Acetyl-CoA Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Ether Lipid Biosynthetic Process Neutrophil Differentiation Monocyte Differentiation Mammary Gland Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cholesterol Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Oxidation-reduction Process Cellular Response To Interleukin-4 Establishment Of Endothelial Intestinal Barrier
Pathways		ChREBP activates metabolic gene expression Vitamin B5 (pantothenate) metabolism Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
Drugs		Cerulenin Orlistat
Diseases
GWAS		Blood protein levels ( 30072576) Major depressive disorder ( 27777418) Malate levels ( 31560688)	Fibrinogen levels ( 26561523) Schizophrenia ( 25056061 29483656) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		7 interacting genes: AKT1 EWSR1 MTDH NDRG1 PRR12 PTEN YWHAQ	2 interacting genes: FASN PUM1
Entrez ID		2194	57479
HPRD ID		02567	19620
Ensembl ID		ENSG00000169710	ENSG00000126464
Uniprot IDs		P49327	Q9ULL5
PDB IDs		1XKT 2CG5 2JFD 2JFK 2PX6 3HHD 3TJM 4PIV 4W82 4W9N 4Z49 5C37 6NNA
Enriched GO Terms of Interacting Partners?
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