PLAC9 and EMILIN1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PLAC9	EMILIN1
Description		placenta associated 9	elastin microfibril interfacer 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Extracellular Region Collagen Trimer Extracellular Space Integrin Alpha4-beta1 Complex Collagen-containing Extracellular Matrix Extracellular Exosome EMILIN Complex
	Molecular Function	Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Integrin Binding Involved In Cell-matrix Adhesion
	Biological Process		Aortic Valve Morphogenesis Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Elastic Fiber Assembly Negative Regulation Of Cell Activation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Macrophage Migration
Pathways			Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848)
Interacting Genes		4 interacting genes: CCDC14 EMILIN1 RAPGEF5 RNF213	15 interacting genes: BEX3 BEX5 COG7 DYNC1I1 EMILIN2 IFT20 LAIR2 MIA2 MTMR9 NECAB2 NMI PLAC9 RIBC1 YJU2 ZC2HC1C
Entrez ID		219348	11117
HPRD ID		18491	00563
Ensembl ID		ENSG00000189129	ENSG00000138080
Uniprot IDs		Q5JTB5 Q5JTB6	Q9Y6C2
PDB IDs			2KA3 2OII
Enriched GO Terms of Interacting Partners?
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