FANCC and HSPA4

Number of citations of the paper that reports this interaction (PubMedID 11500375)
38

Data Source:
BioGRID (affinity chromatography technology, pull down)

		FANCC	HSPA4
Description		FA complementation group C	heat shock protein family A (Hsp70) member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex	Nucleus Cytosol Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding ATP Binding
	Biological Process	Myeloid Cell Homeostasis DNA Repair Nucleotide-excision Repair Germ Cell Development Removal Of Superoxide Radicals Cellular Response To Oxidative Stress Interstrand Cross-link Repair Brain Morphogenesis Protein-containing Complex Assembly Neuronal Stem Cell Population Maintenance	Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Chaperone-mediated Protein Complex Assembly
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes	Regulation of HSF1-mediated heat shock response
Drugs			Phenethyl Isothiocyanate
Diseases		Fanconi anemia
GWAS		Birth weight ( 31043758) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 26284813)	Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Eyebrow thickness ( 26926045) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Reticulocyte fraction of red cells ( 27863252) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		34 interacting genes: AZIN1 CAPN10 CCNA2 CDK1 CTBP1 DNAJB1 FANCA FANCD2 FANCE FANCF FANCG GSTP1 HSP90AA1 HSP90B1 HSPA1A HSPA4 HSPA8 IK KRT1 MEOX2 MT-ATP6 POR PRDX3 PRPF31 RPL18 RPS3A SPTA1 SPTAN1 STAT1 STMN1 STMN2 TCERG1 USP14 ZBTB32	65 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BAG5 BRMS1 CALM1 CD40 CDC73 CDKN2A CSNK1A1 CSNK2A1 DDIT4 DNAJB1 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 RAF1 RAP1A REL RELA SGTA SIRPA SMAD3 ST13 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE3A
Entrez ID		2176	3308
HPRD ID		01967	09025
Ensembl ID		ENSG00000158169	ENSG00000170606
Uniprot IDs		A0A024R9N2 A0A087WW44 B4E3W2 Q00597	P34932
PDB IDs
Enriched GO Terms of Interacting Partners?
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