F2RL2 and CDH5

Number of citations of the paper that reports this interaction (PubMedID 17057644)
38

Data Source:
HPRD (in vivo, in vitro)

		F2RL2	CDH5
Description		coagulation factor II thrombin receptor like 2	cadherin 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Protein-containing Complex	Cell Nucleoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Catenin Complex Cell Junction Nuclear Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding Thrombin-activated Receptor Activity	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Protein Phosphatase Binding Vascular Endothelial Growth Factor Receptor 2 Binding Ion Channel Binding Cadherin Binding Fibrinogen Binding BMP Receptor Binding Protein Tyrosine Kinase Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Blood Coagulation Response To Wounding Platelet Activation Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Thrombin-activated Receptor Signaling Pathway	Cell Morphogenesis Regulation Of Protein Phosphorylation Blood Vessel Maturation Cellular Calcium Ion Homeostasis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organism Development Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein Complex Assembly Adherens Junction Organization Positive Regulation Of Protein Dephosphorylation Regulation Of Vascular Permeability Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)	Adherens junctions interactions VEGFR2 mediated vascular permeability
Drugs			Lenalidomide FX06
Diseases
GWAS		Phenylephrine infusion rate during anesthesia ( 31455332)	Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034)
Interacting Genes		8 interacting genes: CDH5 CTSG ECT2 F11R F2 F2RL3 JAM2 JAM3	21 interacting genes: CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM
Entrez ID		2151	1003
HPRD ID		03561	03075
Ensembl ID		ENSG00000164220	ENSG00000179776
Uniprot IDs		O00254	P33151 Q59EA3
PDB IDs
Enriched GO Terms of Interacting Partners?
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