ETS2 and CDK10

Number of citations of the paper that reports this interaction (PubMedID 11313931)
30

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ETS2	CDK10
Description		ETS proto-oncogene 2, transcription factor	cyclin dependent kinase 10
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane	Nucleus Cytoplasm Ciliary Basal Body
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding	Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ectodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Mesoderm Development Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Primitive Streak Formation	Protein Phosphorylation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of Cell Proliferation Peptidyl-threonine Phosphorylation Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of MAPK Cascade Negative Regulation Of Cilium Assembly
Pathways		Oncogene Induced Senescence
Drugs
Diseases
GWAS		Body mass index ( 25673413) C-reactive protein levels ( 30388399) Eye morphology ( 29921221) Fibrinogen levels ( 28107422) Fractures ( 30158200) Intraocular pressure ( 29617998) Non-small cell lung cancer (survival) ( 21079520) Periodontitis (Mean PAL) ( 24024966) Schizophrenia ( 30285260)	Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Height ( 25429064) Intake of total sugars ( 31005972) Melanoma ( 28212542) Red vs. brown/black hair color ( 30531825)
Interacting Genes		20 interacting genes: CDK10 COP1 CREBBP EP300 ERG ETS1 FOS GATA3 JUN NCOR1 NR3C1 POU5F1 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 ZFYVE9 ZMYND11	3 interacting genes: ETS2 FBXO7 RNF115
Entrez ID		2114	8558
HPRD ID		01263	04588
Ensembl ID		ENSG00000157557	ENSG00000185324
Uniprot IDs		P15036	B7Z537 Q15131
PDB IDs		4BQA 4MHV
Enriched GO Terms of Interacting Partners?
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