EPHA8 and ZNF746

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		EPHA8	ZNF746
Description		EPH receptor A8	zinc finger protein 746
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Early Endosome Membrane Neuron Projection Receptor Complex	Nucleus Cytoplasm
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Substrate-dependent Cell Migration Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Neuron Remodeling Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Cellular Response To Follicle-stimulating Hormone Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Death
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Generic Transcription Pathway
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis ( 19451621) Multiple sclerosis ( 21833088)
Interacting Genes		12 interacting genes: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 LRRK1 PIK3CG PSMC5 PTPRD ZNF746	14 interacting genes: DIABLO DUSP23 EPHA8 FAM118B FES GSK3B HMOX2 ILK MAP3K20 MAP3K7 PRKN PRKRA RPS6KA6 UBE2E3
Entrez ID		2046	155061
HPRD ID		01493	08099
Ensembl ID		ENSG00000070886	ENSG00000181220
Uniprot IDs		P29322	Q6NUN9
PDB IDs		1UCV 1X5L 3KUL
Enriched GO Terms of Interacting Partners?
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