EPHA7 and EFNA5

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		EPHA7	EFNA5
Description		EPH receptor A7	ephrin A5
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuromuscular Junction Neuron Projection Neuronal Cell Body Receptor Complex Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Basement Membrane Plasma Membrane Caveola Adherens Junction Anchored Component Of External Side Of Plasma Membrane GABA-ergic Synapse
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Chemorepellent Activity Ephrin Receptor Binding	Neurotrophin TRKA Receptor Binding Neurotrophin TRKB Receptor Binding Neurotrophin TRKC Receptor Binding Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Chemorepellent Activity Ephrin Receptor Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Brain Development Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Protein Autophosphorylation Positive Regulation Of Kinase Activity Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Negative Regulation Of Collateral Sprouting Branching Morphogenesis Of A Nerve Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Negative Regulation Of Synapse Assembly Regulation Of ERK1 And ERK2 Cascade Nephric Duct Morphogenesis Regulation Of Postsynapse Organization	Positive Regulation Of Protein Phosphorylation Apoptotic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Nervous System Development Axon Guidance Regulation Of Cell-cell Adhesion Regulation Of Cell Morphogenesis Retinal Ganglion Cell Axon Guidance Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Collateral Sprouting Positive Regulation Of Collateral Sprouting Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Regulation Of Focal Adhesion Assembly Positive Regulation Of Synapse Assembly Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Follicle-stimulating Hormone Stimulus Synaptic Membrane Adhesion Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Forskolin
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide
Diseases
GWAS		Adventurousness ( 30643258) Anthropometric traits (multi-trait analysis) ( 30166351) Chin dimples ( 27182965) Dialysis-related mortality ( 21546767) Diisocyanate-induced asthma ( 25918132) Initial pursuit acceleration ( 29064472) Laryngeal squamous cell carcinoma ( 25194280) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to hepatitis C treatment ( 22095909) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Waist circumference adjusted for body mass index ( 28552196)	Alzheimer's disease biomarkers ( 23419831) Atrial fibrillation ( 29892015) Body mass index ( 26426971) Chronotype ( 30696823) Cocaine dependence ( 31212010) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Dentures ( 31235808) Hippocampal atrophy ( 19668339) Household income (MTAG) ( 31844048) Longitudinal cocaine use ( 31591132) Medial orbital frontal cortex volume ( 31530798) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952) Non-del(5q) myelodysplastic syndromes ( 31738830) Nose morphology ( 29921221) Number of children ever born ( 27798627) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Sedentary behaviour duration ( 30531941) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		12 interacting genes: AFDN DUSP18 DUSP26 EFNA1 EFNA3 EFNA4 EFNA5 GNB1 MAP1LC3A MTMR14 STYX ZNF267	10 interacting genes: EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 GRIP1 SRC
Entrez ID		2045	1946
HPRD ID		03721	03324
Ensembl ID		ENSG00000135333	ENSG00000184349
Uniprot IDs		Q15375	D6RDV5 P52803
PDB IDs		2REI 3DKO 3H8M 3NRU	2X11 3MX0 4BK5 4BKA 4L0P 4M4R
Enriched GO Terms of Interacting Partners?
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