EPHA5 and EFNA5

Number of citations of the paper that reports this interaction (PubMedID 10531456)
16

Data Source:
HPRD (in vivo)

		EPHA5	EFNA5
Description		EPH receptor A5	ephrin A5
Image
GO Annotations	Cellular Component	Rough Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Axon Dendrite Neuron Projection Neuronal Cell Body Receptor Complex Perinuclear Region Of Cytoplasm	Basement Membrane Plasma Membrane Caveola Adherens Junction Anchored Component Of External Side Of Plasma Membrane GABA-ergic Synapse
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding	Neurotrophin TRKA Receptor Binding Neurotrophin TRKB Receptor Binding Neurotrophin TRKC Receptor Binding Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Chemorepellent Activity Ephrin Receptor Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Peptidyl-tyrosine Phosphorylation CAMP-mediated Signaling Hippocampus Development Positive Regulation Of CREB Transcription Factor Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Kinase Activity Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Neuron Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Positive Regulation Of Protein Phosphorylation Apoptotic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Nervous System Development Axon Guidance Regulation Of Cell-cell Adhesion Regulation Of Cell Morphogenesis Retinal Ganglion Cell Axon Guidance Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Collateral Sprouting Positive Regulation Of Collateral Sprouting Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Regulation Of Focal Adhesion Assembly Positive Regulation Of Synapse Assembly Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Follicle-stimulating Hormone Stimulus Synaptic Membrane Adhesion Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Forskolin
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		Dasatinib
Diseases
GWAS		Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 22174851) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Severe skin toxicity response to cetuximab in colorectal cancer ( 30557370) Urate levels (BMI interaction) ( 25811787)	Alzheimer's disease biomarkers ( 23419831) Atrial fibrillation ( 29892015) Body mass index ( 26426971) Chronotype ( 30696823) Cocaine dependence ( 31212010) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Dentures ( 31235808) Hippocampal atrophy ( 19668339) Household income (MTAG) ( 31844048) Longitudinal cocaine use ( 31591132) Medial orbital frontal cortex volume ( 31530798) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Neonatal cytokine/chemokine levels (maternal genetic effect) ( 30134952) Non-del(5q) myelodysplastic syndromes ( 31738830) Nose morphology ( 29921221) Number of children ever born ( 27798627) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Sedentary behaviour duration ( 30531941) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		8 interacting genes: DUSP21 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 ERBB2 NEDD4	10 interacting genes: EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 GRIP1 SRC
Entrez ID		2044	1946
HPRD ID		02474	03324
Ensembl ID		ENSG00000145242	ENSG00000184349
Uniprot IDs		A0A384MU00 B7ZKJ3 B7ZKW7 F8VP57 F8W9W0 P54756 Q59FT4	D6RDV5 P52803
PDB IDs		2R2P 4ET7	2X11 3MX0 4BK5 4BKA 4L0P 4M4R
Enriched GO Terms of Interacting Partners?
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