TUBB and SDC3

Number of citations of the paper that reports this interaction (PubMedID 9553134)
53

Data Source:
HPRD (in vitro)

		TUBB	SDC3
Description		tubulin beta class I	syndecan 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Lumen Cytoplasm Cytoskeleton Microtubule Protein-containing Complex Azurophil Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cell Body Membrane Raft Extracellular Exosome	Golgi Lumen Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Lysosomal Lumen Microspike Collagen-containing Extracellular Matrix
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding GTPase Activating Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding	Protein Binding Identical Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cellular Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Neutrophil Degranulation Regulation Of Synapse Organization Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Cell Migration Leukocyte Migration
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport
Drugs		Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Patupilone CYT997 CA4P ZEN-012 Copper Depatuxizumab mafodotin Milataxel
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Handedness (non-right-handed vs right-handed) ( 31504236)	Loneliness ( 27629369)
Interacting Genes		71 interacting genes: ADAP2 ALDOA APP ARL8B ATXN3 B4GALT1 BMPR2 BRCA1 CDKN2A CLIP1 CMTM5 CNN1 CRIPT DISC1 DPYSL2 DYNLL1 ESR1 GDAP1 GRM1 HDAC6 HGS HTRA2 HTT LNX2 MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MTNR1A MX1 NCALD NCAM1 NCAPH2 NDEL1 NPHP1 PFDN4 PLK1 PRKN PTEN RAB8B RACK1 RASSF1 S100A8 S100A9 SDC3 SPP1 STAU1 SUMO2 SYT9 TAOK2 TBCD TGM2 TINF2 TPPP TTBK1 TTK TUBA1A VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 ZFYVE21 ZMYND19	18 interacting genes: CASK COL5A1 CSK CTTN CUX1 EPHB4 FGF2 FYN ITGB4 KRTAP10-3 KRTAP2-4 KRTAP4-2 KRTAP5-9 MDK PTN TUBA1A TUBB TUBB2A
Entrez ID		203068	9672
HPRD ID		01852	01719
Ensembl ID		ENSG00000196230	ENSG00000162512
Uniprot IDs		B4DMJ5 B4DQN9 B4DY90 P07437 Q5ST81 Q5SU16	O75056
PDB IDs		3QNZ 3QO0 5N5N 6I2I 6QUS 6QUY 6QVJ
Enriched GO Terms of Interacting Partners?
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