KHDRBS2 and PTK6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		KHDRBS2	PTK6
Description		KH RNA binding domain containing, signal transduction associated 2	protein tyrosine kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	RNA Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding SH2 Domain Binding Identical Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Identical Protein Binding
	Biological Process	MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Signal Transduction Positive Regulation Of Neuron Projection Development Cell Migration Cell Differentiation Peptidyl-tyrosine Autophosphorylation ERBB2 Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Growth Protein Autophosphorylation Intestinal Epithelial Cell Differentiation Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Retinoic Acid
Pathways		PTK6 Regulates Proteins Involved in RNA Processing	SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling PTK6 Regulates Proteins Involved in RNA Processing PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 PTK6 Regulates Cell Cycle PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 Down-Regulation PTK6 Expression PTK6 Activates STAT3 PTK6 promotes HIF1A stabilization
Drugs			Vandetanib
Diseases
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Chronotype ( 30696823) Corneal astigmatism ( 30306274) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Esophageal adenocarcinoma ( 27527254) Presence of antiphospholipid antibodies ( 27098658) Protein quantitative trait loci ( 18464913)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Hair shape ( 29220522) Prostate cancer ( 23535732)
Interacting Genes		34 interacting genes: AEN CATSPER1 CHTOP CIRBP DOCK2 EWSR1 GRAP2 GRB2 HBZ HNRNPK HNRNPLL KHDRBS3 LINC01018 MTA1 NABP1 NCOA5 NPDC1 PRMT1 PRPF31 PRR3 PSMF1 PTK6 RBM10 RBM3 RBMX SDCBP SPG7 SULT1A3 TMEM14B TYK2 TYMSOS YTHDC1 ZFC3H1 ZNF688	16 interacting genes: APP CCDC33 DOK1 EFHC2 EGFR ERBB3 EXOC5 FCHO1 FGFR1 HIF1A KHDRBS1 KHDRBS2 LINC01139 REL STAP2 WASL
Entrez ID		202559	5753
HPRD ID		13775	03594
Ensembl ID		ENSG00000112232	ENSG00000101213
Uniprot IDs		Q5VWX1	Q13882
PDB IDs			1RJA 2KGT 5D7V 5DA3 5H2U 6CZ2 6CZ3 6CZ4
Enriched GO Terms of Interacting Partners?
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