TIGIT and NECTIN2

Number of citations of the paper that reports this interaction (PubMedID 21982860)
16

Data Source:
BioGRID (pull down)

		TIGIT	NECTIN2
Description		T cell immunoreceptor with Ig and ITIM domains	nectin cell adhesion molecule 2
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Integral Component Of Membrane Cell-cell Contact Zone Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of T Cell Activation	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Spermatid Development Spermatid Nucleus Differentiation Fertilization Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cell Part Morphogenesis Positive Regulation Of Mast Cell Activation Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Viral Entry Into Host Cell Coreceptor-mediated Virion Attachment To Host Cell Regulation Of Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases
GWAS			Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Low density lipoprotein cholesterol levels ( 30498476) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Urate levels ( 31578528)
Interacting Genes		4 interacting genes: NECTIN2 NECTIN3 NECTIN4 PVR	20 interacting genes: AFDN ATP5MF CD226 DUS2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP5-9 LYRM4 MAPK6 MDFI NECTIN3 NECTIN4 NOTCH2NLA PICK1 PVR SIAH1 TIGIT USP53
Entrez ID		201633	5819
HPRD ID		08804	02879
Ensembl ID		ENSG00000181847	ENSG00000130202
Uniprot IDs		Q495A1	Q92692
PDB IDs		3Q0H 3RQ3 3UCR 3UDW 5V52	3R0N 4DFH 4DFI 4HZA 5V52
Enriched GO Terms of Interacting Partners?
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