APLF and XRCC1

Number of citations of the paper that reports this interaction (PubMedID 17353262)
66

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		APLF	XRCC1
Description		aprataxin and PNKP like factor	X-ray repair cross complementing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Site Of Double-strand Break	Nuclear Chromosome, Telomeric Region Nuclear Chromatin Nucleus Nucleoplasm Nucleolus ERCC4-ERCC1 Complex
	Molecular Function	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	Protein Binding Enzyme Binding Oxidized DNA Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity
	Biological Process	Single Strand Break Repair Double-strand Break Repair Cellular Response To DNA Damage Stimulus Regulation Of Isotype Switching Positive Regulation Of DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis	Single Strand Break Repair Double-strand Break Repair Via Homologous Recombination Response To Hypoxia Transcription-coupled Nucleotide-excision Repair Base-excision Repair Base-excision Repair, DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Via Nonhomologous End Joining Response To Organic Substance Negative Regulation Of Protein ADP-ribosylation Cerebellum Morphogenesis Hippocampus Development Response To Hydroperoxide Response To Drug Voluntary Musculoskeletal Movement Telomeric DNA-containing Double Minutes Formation Positive Regulation Of Single Strand Break Repair Positive Regulation Of DNA Ligase Activity Negative Regulation Of Protection From Non-homologous End Joining At Telomere Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways			Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)	Height ( 31562340) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)
Interacting Genes		7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4	19 interacting genes: APEX1 APLF APTX BRCA1 BTRC CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB PSMD8 RNF146 TOPORS UBE2I
Entrez ID		200558	7515
HPRD ID		09848	01909
Ensembl ID		ENSG00000169621	ENSG00000073050
Uniprot IDs		Q8IW19	B2RCY5 P18887 Q59HH7
PDB IDs		2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF	1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC 5E6Q 5W7X 5W7Y
Enriched GO Terms of Interacting Partners?
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