SDR16C5 and NLK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SDR16C5	NLK
Description		short chain dehydrogenase/reductase family 16C member 5	nemo like kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Plasma Membrane Integral Component Of Membrane Transcriptional Repressor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Corepressor Activity Retinol Dehydrogenase Activity Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Activating Transcription Factor Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding SH2 Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Retinol Metabolic Process Retinal Metabolic Process Keratinocyte Proliferation Oxidation-reduction Process	MAPK Cascade Regulation Of Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Regulation Of Gene Expression Peptidyl-threonine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Intracellular Signal Transduction Serine Phosphorylation Of STAT Protein Protein Autophosphorylation Protein Stabilization
Pathways		RA biosynthesis pathway	Ca2+ pathway
Drugs
Diseases
GWAS		Depressive symptoms x dependent stressful life events interaction (2df test) ( 30718454) Height ( 28552196 20881960 31562340)	Non-response to bupropion and depression ( 27622933)
Interacting Genes		2 interacting genes: EXTL1 NLK	23 interacting genes: ASGR1 ATXN1 CREBBP CUL1 FBXW5 FOXO4 FOXP3 GRN HIPK2 KRTAP10-3 KRTAP4-2 KRTAP5-6 KRTAP5-9 LEF1 MYB MYBL1 QRICH1 RCHY1 SDR16C5 SKP2 STAT3 USP4 ZHX3
Entrez ID		195814	51701
HPRD ID		12351	17637
Ensembl ID		ENSG00000170786	ENSG00000087095
Uniprot IDs		B3KT84 G3V145 Q8N3Y7	A0A024QZ12 Q9UBE8
PDB IDs
Enriched GO Terms of Interacting Partners?
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