EEF1G and KARS1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		EEF1G	KARS1
Description		eukaryotic translation elongation factor 1 gamma	lysyl-tRNA synthetase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Membrane Extracellular Exosome	Extracellular Space Nucleus Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	Translation Elongation Factor Activity Protein Binding Cadherin Binding	TRNA Binding ATP Adenylyltransferase Activity Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Translational Elongation Response To Virus	Activation Of MAPK Activity Basophil Activation Involved In Immune Response Positive Regulation Of Cytokine Secretion Involved In Immune Response TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Negative Regulation Of Cell Proliferation Response To X-ray Positive Regulation Of Macrophage Chemotaxis Diadenosine Tetraphosphate Biosynthetic Process Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of Metallopeptidase Activity
Pathways		Eukaryotic Translation Elongation	Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation
Drugs			L-Lysine
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		88 interacting genes: ABCC9 ADAP2 AKT1 ARF1 ARIH2 C11orf58 C1orf174 CARS1 CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DRD3 ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EID2B ENOX1 FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS1 HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS1 KLHL18 LARS1 LZTS1 MCRIP2 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRF PTPRS RBM6 RECQL5 RGL2 RPL4P5 RPS28 SAT1 SKIL SNAPIN SNRPD2 SUMO2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 WDR33 YWHAG ZBED8 ZDHHC17 ZNF24	16 interacting genes: AIMP2 DARS2 EEF1D EEF1G ESR1 FRS3 GAPDH GEMIN4 MAPK1 PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 SPTAN1 VIM
Entrez ID		1937	3735
HPRD ID		11745	03249
Ensembl ID		ENSG00000254772	ENSG00000065427
Uniprot IDs		P26641 Q53YD7	Q15046
PDB IDs		1PBU 5DQS 5JPO	3BJU 4DPG 4YCU 4YCW 6CHD 6ILD 6ILH
Enriched GO Terms of Interacting Partners?
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