PHC1 and PIAS2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PHC1	PIAS2
Description		polyhomeotic homolog 1	protein inhibitor of activated STAT 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Multicellular Organism Development Histone Ubiquitination Negative Regulation Of G0 To G1 Transition	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Antisaccade task score ( 31596458) Cholesterol, total ( 24097068) Height ( 31562340) Prepulse inhibition of the startle response ( 31596458) Small cell lung carcinoma ( 28604730) Total cholesterol levels ( 28334899)
Interacting Genes		17 interacting genes: BMI1 GMNN HSPA8 PHC2 PIAS2 PPP1CA PPP1CC RING1 RNF2 SCMH1 SFMBT1 SIAH1 SP100 SUMO1 SUMO1P1 UBE2I ZCCHC7	72 interacting genes: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CDCA8 CHMP4B CLDN2 CREBBP CTBP1 DDX39B DNMT3A ELK1 ESR1 ESR2 FLI1 GFAP GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 JUN LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I UBE2L3 ZBED1 ZBTB8A ZNF451
Entrez ID		1911	9063
HPRD ID		16009	06944
Ensembl ID		ENSG00000111752	ENSG00000078043
Uniprot IDs		P78364 Q6GMQ3 Q6N083	A0A024RC49 O75928 Q2TA77
PDB IDs		2L8E	2ASQ 4FO9
Enriched GO Terms of Interacting Partners?
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