EDNRB and EDN3

Number of citations of the paper that reports this interaction (PubMedID 8001160)
160

Data Source:
HPRD (in vivo)

		EDNRB	EDN3
Description		endothelin receptor type B	endothelin 3
Image
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Nuclear Membrane Membrane Raft	Extracellular Region Extracellular Space Cell
	Molecular Function	Endothelin Receptor Activity Protein Binding Peptide Hormone Binding Type 1 Angiotensin Receptor Binding	Signaling Receptor Binding Hormone Activity Endothelin B Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Regulation Of PH Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Peripheral Nervous System Development Posterior Midgut Development Aging Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Negative Regulation Of Neuron Maturation Response To Organic Cyclic Compound Vein Smooth Muscle Contraction Sensory Perception Of Pain Calcium-mediated Signaling CGMP-mediated Signaling Melanocyte Differentiation Regulation Of Fever Generation Negative Regulation Of Cellular Protein Metabolic Process Enteric Smooth Muscle Cell Differentiation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Epithelial Fluid Transport Vasoconstriction Vasodilation Negative Regulation Of Apoptotic Process Macrophage Chemotaxis Response To Pain Enteric Nervous System Development Regulation Of Epithelial Cell Proliferation Regulation Of Sensory Perception Of Pain Positive Regulation Of Penile Erection Cellular Response To Lipopolysaccharide Endothelin Receptor Signaling Pathway Response To Endothelin	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Cellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organism Development Blood Circulation Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Regulation Of Gene Expression Cellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Neutrophil Chemotaxis Vasoconstriction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Regulation Of Developmental Pigmentation Positive Regulation Of Potassium Ion Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Bosentan Sitaxentan Ambrisentan Macitentan
Diseases		Hirschsprung disease (HD) ABCD syndrome Nasopharyngeal cancer Waardenburg syndrome (WS)	Hirschsprung disease (HD) Congenital central hypoventilation syndrome (CCHS) Waardenburg syndrome (WS)
GWAS		Craniofacial microsomia ( 26853712) Hair color ( 23548203 29662168) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)	Blood pressure ( 21909110) Diastolic blood pressure ( 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Hypertension ( 19430479 21909115) Metabolite levels ( 23823483) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858)
Interacting Genes		8 interacting genes: CAV1 EDN1 EDN3 GNA11 GNA13 GRK6 MYCBP2 NOS3	5 interacting genes: CMA1 CTSE EDNRA EDNRB KEL
Entrez ID		1910	1908
HPRD ID		08834	00570
Ensembl ID		ENSG00000136160	ENSG00000124205
Uniprot IDs		A0A024R638 A0A024R645 P24530	P14138 Q4FAT2
PDB IDs		5GLH 5GLI 5X93 5XPR 6IGK 6IGL	6IGK
Enriched GO Terms of Interacting Partners?
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