DNMT1 and ELAVL3

		DNMT1	ELAVL3
Description		DNA methyltransferase 1	ELAV like RNA binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin	Ribonucleoprotein Complex
	Molecular Function	DNA Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity Promoter-specific Chromatin Binding	MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Ras Protein Signal Transduction Maintenance Of DNA Methylation DNA Methylation On Cytosine Within A CG Sequence Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Silencing DNA Methylation Involved In Embryo Development Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine Positive Regulation Of Methylation-dependent Chromatin Silencing Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	Nervous System Development Cell Differentiation
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation
Drugs		Azacitidine Procainamide Flucytosine Decitabine Epigallocatechin Gallate
Diseases
GWAS		Birth weight ( 31043758) Immature fraction of reticulocytes ( 27863252) Narcolepsy ( 24204295) Offspring birth weight ( 31043758) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Diastolic blood pressure ( 27618452) Presence of antiphospholipid antibodies ( 27098658) Systolic blood pressure ( 27618452)
Interacting Genes		40 interacting genes: AKT1 BAZ2A BRAP CBX1 CSNK2B DAXX DCAF5 DMAP1 DNASE2 DNM2 DNMT3A DNMT3B DYNLL1 E2F6 EED ELAVL3 EZH2 GSK3B H3-4 HDAC1 HDAC2 HELLS HMGB1 L3MBTL3 LASP1 MECP2 NRIP1 PCNA PRKAA2 RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUV39H1 TRIM27 TSG101 UBB YWHAQ	10 interacting genes: A2M CDC37 DNMT1 ECSIT ELAVL2 EWSR1 MAST1 NOS3 RNF32 SRPK2
Entrez ID		1786	1995
HPRD ID		00532	16024
Ensembl ID		ENSG00000130816	ENSG00000196361
Uniprot IDs		I6L9H2 P26358 Q59FP7	Q14576
PDB IDs		3EPZ 3PTA 3SWR 4WXX 4YOC 4Z96 4Z97 5WVO 5YDR
Enriched GO Terms of Interacting Partners?
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