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AGER and HMGB1
Number of citations of the paper that reports this interaction (PubMedID
9812979
)
14
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
AGER
HMGB1
Description
advanced glycosylation end-product specific receptor
high mobility group box 1
Image
GO Annotations
Cellular Component
Fibrillar Center
Extracellular Region
Cell
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Apical Plasma Membrane
Cell Junction
Postsynapse
Nuclear Chromatin
Condensed Chromosome
Extracellular Region
Extracellular Space
Cell
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cell Surface
Transcriptional Repressor Complex
Secretory Granule Lumen
Alphav-beta3 Integrin-HMGB1 Complex
Ficolin-1-rich Granule Lumen
Molecular Function
Amyloid-beta Binding
Transmembrane Signaling Receptor Activity
Scavenger Receptor Activity
Protein Binding
Signaling Receptor Activity
Identical Protein Binding
S100 Protein Binding
Protein-containing Complex Binding
Advanced Glycation End-product Receptor Activity
Four-way Junction DNA Binding
Bubble DNA Binding
Lipopolysaccharide Binding
Phosphatidylserine Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
RNA Binding
Cytokine Activity
Integrin Binding
Protein Binding
Transcription Factor Binding
DNA Binding, Bending
Lyase Activity
C-X-C Chemokine Binding
Chemoattractant Activity
Transcription Regulatory Region DNA Binding
RAGE Receptor Binding
DNA Polymerase Binding
Repressing Transcription Factor Binding
Supercoiled DNA Binding
Biological Process
Response To Hypoxia
Microglial Cell Activation
Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Protein Phosphorylation
Endocytosis
Inflammatory Response
Cell Surface Receptor Signaling Pathway
Learning Or Memory
Response To Wounding
Glucose Mediated Signaling Pathway
Neuron Projection Development
Negative Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Heterotypic Cell-cell Adhesion
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process
Positive Regulation Of JUN Kinase Activity
Transcytosis
Positive Regulation Of Chemokine Biosynthetic Process
Innate Immune Response
Positive Regulation Of Interleukin-6 Biosynthetic Process
Positive Regulation Of JNK Cascade
Astrocyte Activation
Regulation Of Synaptic Plasticity
Positive Regulation Of Interleukin-1 Beta Biosynthetic Process
Induction Of Positive Chemotaxis
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of DNA Binding
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Protein Localization To Membrane
Modulation Of Age-related Behavioral Decline
Regulation Of Spontaneous Synaptic Transmission
Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Long-term Synaptic Depression
Regulation Of P38MAPK Cascade
Positive Regulation Of P38MAPK Cascade
Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Negative Regulation Of Blood Circulation
Positive Regulation Of Endothelin Secretion
Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Response To Amyloid-beta
Cellular Response To Amyloid-beta
Positive Regulation Of Monocyte Extravasation
Regulation Of CD4-positive, Alpha-beta T Cell Activation
Positive Regulation Of Dendritic Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Myeloid Dendritic Cell Activation
Activation Of Innate Immune Response
Toll-like Receptor Signaling Pathway
Dendritic Cell Chemotaxis
Inflammatory Response To Antigenic Stimulus
Regulation Of Tolerance Induction
Regulation Of T Cell Mediated Immune Response To Tumor Cell
DNA Topological Change
Apoptotic DNA Fragmentation
DNA Recombination
Chromatin Remodeling
Chromatin Silencing
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Autophagy
Inflammatory Response
Positive Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Signaling Receptor Activity
Positive Regulation Of Autophagy
Viral Process
Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly
Neuron Projection Development
Regulation Of Restriction Endodeoxyribonuclease Activity
DNA Geometric Change
Positive Regulation Of Mismatch Repair
Developmental Process
Negative Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
V(D)J Recombination
Positive Regulation Of Toll-like Receptor 9 Signaling Pathway
T-helper 1 Cell Activation
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Apoptotic Process
Apoptotic Cell Clearance
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Neutrophil Degranulation
Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of DNA Binding
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
T-helper 1 Cell Differentiation
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Interleukin-1 Secretion
Positive Regulation Of Interleukin-1 Beta Secretion
Positive Chemotaxis
DNA Ligation Involved In DNA Repair
Positive Regulation Of DNA Ligation
Cell Chemotaxis
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Positive Regulation Of Monocyte Chemotaxis
Neutrophil Clearance
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Interferon-alpha Secretion
Positive Regulation Of Vascular Endothelial Cell Proliferation
Tumor Necrosis Factor Secretion
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Apoptotic Cell Clearance
Positive Regulation Of Interleukin-6 Secretion
Positive Regulation Of Dendritic Cell Differentiation
Pathways
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Advanced glycosylation endproduct receptor signaling
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
Apoptosis induced DNA fragmentation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
Drugs
Ethyl pyruvate
Diseases
GWAS
Advanced glycation end-product levels (
26083729
)
Asthma (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
29875488
)
Blood protein levels in cardiovascular risk (
28369058
)
Chronic obstructive pulmonary disease (
28166215
30804561
)
Emphysema imaging phenotypes (
26030696
)
FEV1 (
30804560
)
Inflammatory bowel disease (
28067908
)
Lung function (FEV1/FVC) (
28166213
30804560
)
Lung function (FVC) (
30804560
)
Peak expiratory flow (
30804560
)
Percentage gas trapping (
26030696
)
Prostate cancer (
23535732
)
Pulmonary function (
20010834
20010835
)
Pulmonary function (smoking interaction) (
23284291
)
Response to Pazopanib in cancer (hepatotoxicity) (
26546620
)
Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) (
26651848
)
Ulcerative colitis (
28067908
)
Blood osmolality (transformed sodium) (
28360221
)
Carotid plaque burden (
28282560
)
Hippocampal volume (
21116278
)
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular volume (
27863252
)
Type 2 diabetes (
30297969
)
Urate levels (
31578528
)
Interacting Genes
8 interacting genes:
APP
CREB3
HMGB1
S100A1
S100A12
S100B
S100P
TTR
94 interacting genes:
ACBD3
AGER
AGTRAP
AR
ATOH1
C1QBP
C3
CASP3
CCAR1
CDK1
CEBPB
CREBBP
CRMP1
CSNK1A1
CTCF
CTNNBL1
CUX1
DNM2
DNMT1
EIF1
ENAH
EP300
ERF
ERG28
FIP1L1
FOXA3
FOXC1
GTF2A1
HES1
HMGA1
HNRNPK
HOXB1
HOXB3
HOXC6
HOXD10
HOXD11
HOXD3
HOXD8
HOXD9
HPF1
HR
HSPA5
IRF2
KRT7
LRIF1
MECP2
MNT
MT2A
NCAN
NEUROD6
NEXN
NFKB1
NR3C1
PCOLCE
PGR
PLAT
PLG
POU5F1
PPP2R3A
PRKCA
PRKDC
PSEN1
PTPRZ1
RAD23B
RAG1
RASSF4
RB1
RBPJ
RELA
RFX1
RPL29
RPS12
RPS20
SIX5
SOX18
SPINT1
TAF1
TBP
TERF2
TERF2IP
TFE3
TGIF1
TLE1
TLE2
TLE5
TLR2
TLR4
TP53
TP73
UBE2I
UNC119
ZFP36
ZNF24
ZNF428
Entrez ID
177
3146
HPRD ID
02568
01228
Ensembl ID
ENSG00000204305
ENSG00000189403
Uniprot IDs
A0A1U9X785
B4DNX3
Q15109
A0A024RDR0
P09429
PDB IDs
1PWI
2BJP
2E5E
2ENS
2L7U
2LE9
2LMB
2M1K
2MJW
2MOV
3CJJ
3O3U
4LP4
4LP5
4OF5
4OFV
4OI7
4OI8
4P2Y
4XYN
4YBH
5D7F
2LY4
2RTU
2YRQ
6CG0
6CIJ
6CIK
6CIL
6CIM
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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