ACAN and ADAMTS1

Number of citations of the paper that reports this interaction (PubMedID 12054629)
63

Data Source:
HPRD (in vitro)

		ACAN	ADAMTS1
Description		aggrecan	ADAM metallopeptidase with thrombospondin type 1 motif 1
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix Perisynaptic Extracellular Matrix Glutamatergic Synapse GABA-ergic Synapse	Basement Membrane Cytoplasmic Vesicle Collagen-containing Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding	Metalloendopeptidase Activity Heparin Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Skeletal System Development Cartilage Condensation Chondrocyte Development Proteolysis Cell Adhesion Central Nervous System Development Heart Development Keratan Sulfate Biosynthetic Process Proteoglycan Biosynthetic Process Extracellular Matrix Organization Collagen Fibril Organization Keratan Sulfate Catabolic Process	Ovulation From Ovarian Follicle Kidney Development Proteolysis Integrin-mediated Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Angiogenesis Heart Trabecula Formation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs		GM6001
Diseases		Spondyloepiphyseal dysplasia, Kimberley type Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis
GWAS		Age-related hearing impairment ( 27764096) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Dupuytren's disease ( 28886342) Height ( 21998595 28552196 20881960 25282103 25133637 25429064 23563607 31562340 28270201 18391952) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Alzheimer's disease (late onset) ( 30820047) Blood protein levels ( 28240269) Cerebrospinal fluid neurofilament light levels ( 31930058) Health literacy ( 31250787) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 TNFAIP6 TNR	9 interacting genes: A2M ACAN ADRA2B FAM32A FURIN JAML TPSAB1 VCAN VEGFA
Entrez ID		176	9510
HPRD ID		01123	05530
Ensembl ID		ENSG00000157766	ENSG00000154734
Uniprot IDs		P16112	B2RB33 Q9UHI8
PDB IDs		4MD4	2JIH 2V4B 3Q2G 3Q2H
Enriched GO Terms of Interacting Partners?
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