DNM1 and MAP3K10

Number of citations of the paper that reports this interaction (PubMedID 9742220)
4

Data Source:
BioGRID (pull down)

		DNM1	MAP3K10
Description		dynamin 1	mitogen-activated protein kinase kinase kinase 10
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GO Annotations	Cellular Component	Photoreceptor Inner Segment Nucleoplasm Cytoplasm Golgi Apparatus Microtubule Plasma Membrane Synaptic Vesicle Postsynaptic Density Microtubule Cytoskeleton Membrane Membrane Coat Axon Cytoplasmic Vesicle Mitochondrial Membrane Varicosity Dendritic Spine Dendritic Spine Head Synapse Postsynaptic Membrane Extracellular Exosome Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone Membrane Postsynaptic Endocytic Zone Membrane Glutamatergic Synapse	Cytoplasm
	Molecular Function	RNA Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Protein C-terminus Binding SH3 Domain Binding Protein Kinase Binding D2 Dopamine Receptor Binding Identical Protein Binding Protein-containing Complex Binding Nitric-oxide Synthase Binding	Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity ATP Binding Protein Homodimerization Activity BHLH Transcription Factor Binding
	Biological Process	Mitochondrial Fission G Protein-coupled Receptor Internalization Endocytosis Receptor-mediated Endocytosis Endosome Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Receptor Internalization Ephrin Receptor Signaling Pathway Organelle Fission Regulation Of Synapse Structure Or Activity Modulation Of Chemical Synaptic Transmission Membrane Fusion Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Synaptic Vesicle Endocytosis Toxin Transport Response To Amyloid-beta	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057) Body mass index ( 26426971) Coenzyme Q10 levels ( 27149984)	Birth weight ( 31043758) Resting heart rate ( 27798624)
Interacting Genes		46 interacting genes: AMPH AP2A2 ASB13 BIN1 CABIN1 CAV1 CDK5 CEP126 CLIC3 CLIC4 CLINT1 CTTN DNM2 DNMBP EPS15 FNBP1 GRB2 GRIN1 GRIN2D ITSN1 MAP3K10 MED31 MOB4 NCK1 NCK2 NME2 PACSIN1 PACSIN2 PACSIN3 PFN2 PIAS1 PIK3R1 PIN4 PLCG1 PRKCA PRNP RACK1 SH3GL1 SH3GL2 SH3GL3 SNAP25 SNX9 SRC SUMO1 TIMM50 UBE2I	31 interacting genes: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP3K21 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE
Entrez ID		1759	4294
HPRD ID		03851	02533
Ensembl ID		ENSG00000106976	ENSG00000130758
Uniprot IDs		B4DK06 B7ZAC0 Q05193	Q02779
PDB IDs		1DYN 2DYN 2X2E 2X2F 3SNH 3ZYC 3ZYS 4UUD 4UUK 5D3Q 6DLU 6DLV	2RF0
Enriched GO Terms of Interacting Partners?
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