DLAT and PRKD3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		DLAT	PRKD3
Description		dihydrolipoamide S-acetyltransferase	protein kinase D3
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex	Nucleoplasm Cytosol Membrane
	Molecular Function	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Identical Protein Binding	Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Sleep	Protein Phosphorylation Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Sphingolipid Biosynthetic Process Protein Kinase D Signaling
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Sphingolipid de novo biosynthesis
Drugs		NADH Radicicol Dihydrolipoic Acid
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS			Body mass index ( 28892062) Chronic lymphocytic leukemia ( 28165464 24292274) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Pulse pressure ( 27841878) Schizophrenia ( 23974872) Systolic blood pressure ( 28135244 27841878)
Interacting Genes		7 interacting genes: PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3	9 interacting genes: BCL6 DLAT GSK3A IKBKG KPNA2 KPNB1 NUDT3 SKA2 VAMP2
Entrez ID		1737	23683
HPRD ID		10578	06151
Ensembl ID		ENSG00000150768	ENSG00000115825
Uniprot IDs		P10515 Q86YI5	O94806
PDB IDs		1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55	2D9Z
Enriched GO Terms of Interacting Partners?
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