DIO2 and USP20

Number of citations of the paper that reports this interaction (PubMedID 12865408)
52

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro, two hybrid)

		DIO2	USP20
Description		iodothyronine deiodinase 2	ubiquitin specific peptidase 20
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Cytoplasm Centrosome Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding Thyroxine 5-deiodinase Activity	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity
	Biological Process	Selenocysteine Incorporation Thyroid Hormone Generation Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Brown Fat Cell Differentiation Oxidation-reduction Process Positive Regulation Of Cold-induced Thermogenesis	Ubiquitin-dependent Protein Catabolic Process Endocytosis Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Regulation of thyroid hormone activity	Ub-specific processing proteases
Drugs
Diseases
GWAS		Free thyroxine concentration ( 30367059) Metabolite levels ( 23823483) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Rosacea symptom severity ( 29771307)	Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: MARCHF6 UBE2G1 UBE2J1 USP20 USP33 WSB1	28 interacting genes: ALAS1 BEND5 BEND7 CLSPN DIO2 FATE1 GTF2IRD1 HIF1A IHO1 LMNA MAGEA11 MAPK6 MDFI PJA1 PLA2G2A PRKACA PRKCI RAD17 SPRY2 STING1 TRIM23 UBC ULK1 USP15 USP21 USP28 VAPB VHL
Entrez ID		1734	10868
HPRD ID		09027	07505
Ensembl ID		ENSG00000211448	ENSG00000136878
Uniprot IDs		A8K845 Q92813	Q9Y2K6
PDB IDs			6KCZ
Enriched GO Terms of Interacting Partners?
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