PPP1R18 and STX11

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PPP1R18	STX11
Description		protein phosphatase 1 regulatory subunit 18	syntaxin 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton	Golgi Apparatus Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane SNARE Complex Presynaptic Membrane Presynaptic Active Zone Membrane
	Molecular Function	Actin Binding Protein Binding Phosphatase Binding	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process		Intracellular Protein Transport Exocytosis Vesicle Fusion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Docking Membrane Fusion
Pathways
Drugs
Diseases			Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Lung cancer ( 28604730)	Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		37 interacting genes: CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC57 DES FAM9B FSD2 GOLGA2 HOMER3 KASH5 KCTD9 KRT13 KRT15 KRT19 KRT31 KRT40 LZTS2 MID2 MTUS2 NEFL PDE4DIP PPP1CA PPP1CC SPDL1 STX11 TCF4 TEX11 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TRIM69 TSGA10 VPS52	64 interacting genes: APP AXIN1 BLOC1S6 BYSL C1orf109 CARD9 CCBE1 CCDC184 CCDC33 CCNK CDCA7L CRYBA4 CTBP2 CWF19L2 EIF1AD FAM110A FAM161A FAM74A4 FAM90A1 FARS2 GOLGA8EP GOLGA8F HAUS1 HGS IKBKG IKZF3 KAT5 KCTD9 KDM1A KLC3 KXD1 LENG1 LONRF1 MBIP MEOX2 MFAP1 MID2 NDC80 NTAQ1 PPP1R18 PRKAB2 PRPF31 PSMA3 PSMC3 RNF6 RUNX1T1 SH2D4A SLC38A2 SMARCE1 SNAP23 SNAP25 SNX3 SUV39H1 TAF6L TBK1 TCF4 TLE5 TNFRSF21 USHBP1 VAMP2 VPS52 ZCCHC10 ZNF417 ZNF587
Entrez ID		170954	8676
HPRD ID		11172	09231
Ensembl ID		ENSG00000146112	ENSG00000135604
Uniprot IDs		A0A024RCJ8 Q6NYC8	O75558
PDB IDs
Enriched GO Terms of Interacting Partners?
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