DEDD2 and NR2E3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		DEDD2	NR2E3
Description		death effector domain containing 2	nuclear receptor subfamily 2 group E member 3
Image		No pdb structure
GO Annotations	Cellular Component	Cell Nucleoplasm Nucleolus	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	DNA Binding Protein Binding Receptor Signaling Complex Scaffold Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	RNA Processing Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors RRNA Catabolic Process Cellular Homeostasis Apoptotic Nuclear Changes Intracellular Signal Transduction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Visual Perception Phototransduction Negative Regulation Of Cell Proliferation Cell Differentiation Intracellular Receptor Signaling Pathway Eye Photoreceptor Cell Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Rhodopsin Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development Retina Development In Camera-type Eye
Pathways
Drugs
Diseases			Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Retinitis pigmentosa (RP)
GWAS			Macular thickness ( 30535121) Metabolite levels (HVA/MHPG ratio) ( 23319000)
Interacting Genes		11 interacting genes: CASP10 CASP8 CDCA7L CDK6 CFLAR DEDD GTF3C3 HNRNPAB NR2E3 RBFOX2 RHOXF2	28 interacting genes: BCL11A CDK9 CRX DEDD2 DHX30 ELAVL2 HDAC1 HDAC3 HOXC13 IRF9 MYBBP1A NCOR1 NR1D1 NR3C1 NRL POLR3D PPARG RARA RBBP4 RBBP7 RBFOX2 RBL1 RXRA RXRB SIN3A SNAPC1 TBL3 ZNF232
Entrez ID		162989	10002
HPRD ID		10868	05132
Ensembl ID		ENSG00000160570	ENSG00000278570
Uniprot IDs		Q8WXF8	F1D8Q9 Q9Y5X4
PDB IDs			4LOG
Enriched GO Terms of Interacting Partners?
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