AMOT and LATS2

Number of citations of the paper that reports this interaction (PubMedID 24255178)
147

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology, enzymatic study, enzymatic study, enzymatic study)

		AMOT	LATS2
Description		angiomotin	large tumor suppressor kinase 2
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GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytosol Actin Filament Plasma Membrane Bicellular Tight Junction COP9 Signalosome External Side Of Plasma Membrane Lamellipodium Cell Junction Endocytic Vesicle Cytoplasmic Vesicle	Spindle Pole Nucleus Cytosol Centriolar Satellite
	Molecular Function	Protein Binding Signaling Receptor Activity Angiostatin Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Angiogenesis Vasculogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Chemotaxis Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Migration Negative Regulation Of GTPase Activity Cellular Protein Localization Hippo Signaling Positive Regulation Of Embryonic Development Cell Migration Involved In Gastrulation Blood Vessel Endothelial Cell Migration Regulation Of Small GTPase Mediated Signal Transduction	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Hormone-mediated Signaling Pathway Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS			3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134)
Interacting Genes		21 interacting genes: ACTA1 APP C1orf216 KRT15 KRT31 LATS2 LMO4 LURAP1 MAGEA4 MAGI1 MAPK3 MED4 NEDD4 NEDD4L NTAQ1 PIN1 PLG PTPA SEPTIN1 SNAPC5 UNC119	71 interacting genes: ABL1 AJUBA AKT1 AMOT ARAF ARNT AURKA AURKB BECN1 BRAF CBLC CCND2 CCNE1 CD44 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C CHEK1 CHEK2 CTNNB1 DYRK1A EPHA2 ERBB2 EZH2 FGFR4 FHL3 FZR1 GLIS1 GLIS2 GRAP2 GRM1 HGF HIF1A KAT2A KDELR2 KIF23 MAP2K3 MAP2K5 MAP3K5 MAPK14 MDM4 MET MOB3A MOB3B MOB3C MOB4 MYC NF2 NFIC PDGFRA RAF1 RASSF1 RELA SMAD2 SNAI1 STK11 STK3 STK4 SUZ12 TAZ TEAD2 TP53 TSC1 WWTR1 YAP1 YWHAG YWHAZ
Entrez ID		154796	26524
HPRD ID		02327	07277
Ensembl ID		ENSG00000126016	ENSG00000150457
Uniprot IDs		Q4VCS5	A0A024RDM3 Q9NRM7
PDB IDs		6JJX	4ZRI
Enriched GO Terms of Interacting Partners?
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