CYP1A2 and POR

Number of citations of the paper that reports this interaction (PubMedID 9398194)
40

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		CYP1A2	POR
Description		cytochrome P450 family 1 subfamily A member 2	cytochrome p450 oxidoreductase
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Enzyme Binding Heme Binding Demethylase Activity Caffeine Oxidase Activity Aromatase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity	NADPH-hemoprotein Reductase Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Nitric Oxide Dioxygenase Activity Electron Transfer Activity FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Hydrolase Activity Enzyme Binding Iron-cytochrome-c Reductase Activity Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Steroid Catabolic Process Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Toxin Biosynthetic Process Post-embryonic Development Alkaloid Metabolic Process Regulation Of Gene Expression Monoterpenoid Metabolic Process Drug Metabolic Process Dibenzo-p-dioxin Metabolic Process Epoxygenase P450 Pathway Electron Transport Chain Lung Development Methylation Response To Estradiol Response To Lipopolysaccharide Monocarboxylic Acid Metabolic Process Response To Immobilization Stress Retinol Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Cellular Respiration Heterocycle Metabolic Process Hydrogen Peroxide Biosynthetic Process Oxidation-reduction Process Oxidative Demethylation Cellular Response To Cadmium Ion Cellular Response To Copper Ion Oxidative Deethylation Omega-hydroxylase P450 Pathway	Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Xenobiotic Metabolic Process Response To Nutrient Carnitine Metabolic Process Response To Hormone Flavonoid Metabolic Process Internal Peptidyl-lysine Acetylation Fatty Acid Oxidation Electron Transport Chain Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Monooxygenase Activity Response To Drug Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nitrate Catabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Smoothened Signaling Pathway Nitric Oxide Catabolic Process Oxidation-reduction Process Negative Regulation Of Lipase Activity Demethylation Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Steroid Hormone Biosynthetic Process Cellular Organofluorine Metabolic Process
Pathways		Methylation Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Aflatoxin activation and detoxification Biosynthesis of protectins Biosynthesis of maresin-like SPMs	Cytochrome P450 - arranged by substrate type
Drugs		Isoniazid 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE Diacerein	Flavin adenine dinucleotide Riboflavin Monophosphate 2'-Monophosphoadenosine 5'-Diphosphoribose
Diseases			46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS		Bladder cancer ( 25281661) Caffeine consumption ( 21490707) Coffee consumption ( 21876539 21357676 25288136) Coffee consumption (cups per day) ( 25288136) Diastolic blood pressure ( 19430483) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Plasma clozapine levels in treatment-resistant schizophrenia ( 30922102) Red blood cell count ( 27863252) Serum albumin level ( 29403010) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)	Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Coffee consumption ( 31046077 25288136) Coffee consumption (cups per day) ( 25288136) Estimated glomerular filtration rate ( 31152163 31451708) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		2 interacting genes: CYB5A POR	20 interacting genes: CYB5A CYP17A1 CYP1A2 CYP2A6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 EHMT2 FANCC HMOX1 PSPHP1 RABEPK RPS4X SIN3B SLC39A2 STAT1 TGFBI XRCC6
Entrez ID		1544	5447
HPRD ID		00489	00485
Ensembl ID		ENSG00000140505	ENSG00000127948
Uniprot IDs		P05177	P16435
PDB IDs		2HI4	1B1C 3FJO 3QE2 3QFC 3QFR 3QFS 3QFT 5EMN 5FA6
Enriched GO Terms of Interacting Partners?
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