KLB and FGFR1

Number of citations of the paper that reports this interaction (PubMedID 17623664)
228

Data Source:
BioGRID (imaging technique, fluorescent resonance energy transfer, affinity chromatography technology)

		KLB	FGFR1
Description		klotho beta	fibroblast growth factor receptor 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Nucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Receptor Complex
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Fibroblast Growth Factor Receptor Binding Protein Binding Fibroblast Growth Factor Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Receptor-receptor Interaction
	Biological Process	MAPK Cascade Carbohydrate Metabolic Process Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Skeletal System Development Angiogenesis Ureteric Bud Development In Utero Embryonic Development Organ Induction Neuron Migration Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Sensory Perception Of Sound Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Positive Regulation Of Phospholipase C Activity Regulation Of Phosphate Transport Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Ventricular Zone Neuroblast Division Embryonic Limb Morphogenesis Midbrain Development Positive Regulation Of Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Inner Ear Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Chordate Embryonic Development Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Protein Autophosphorylation Phosphatidylinositol-mediated Signaling Paraxial Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Cell Maturation Skeletal System Morphogenesis Mesenchymal Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Auditory Receptor Cell Development Branching Involved In Salivary Gland Morphogenesis Lung-associated Mesenchyme Development Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Vitamin D3 Metabolic Process Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Parathyroid Hormone Secretion Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		PI3K Cascade PIP3 activates AKT signaling betaKlotho-mediated ligand binding Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR4 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR4 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Signaling by activated point mutants of FGFR1 Signaling by FGFR1 in disease Signaling by plasma membrane FGFR1 fusions
Drugs			Palifermin Sorafenib Heparin SU4984 XL999 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine (E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE Regorafenib Ponatinib Lenvatinib Nintedanib
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Hypogonadotropic hypogonadism; Kallmann syndrome (KAL) Osteoglophonic dysplasia (OD); Osteoglophonic dwarfism (OGD) Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Alcohol consumption ( 27911795 28937693 31358974) Alcohol consumption (drinks per week) ( 28485404 30643258 30679032) Alcohol consumption in current drinkers ( 28937693) Alcohol use disorder (consumption score) ( 30940813 30336701) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Asthma ( 30929738) Asthma (adult onset) ( 30929738) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Pulse pressure ( 30578418) Urate levels ( 31578528)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Birth weight ( 31043758) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Nonsyndromic cleft lip with cleft palate ( 28232668) PR interval ( 30046033) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Schizophrenia ( 29483656)
Interacting Genes		2 interacting genes: FGF21 FGFR1	64 interacting genes: BNIP2 CDH1 CREBBP CRK CTPS2 EPHA4 ERBB2 ERBB3 FBXO7 FDPS FGF1 FGF10 FGF17 FGF18 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FLRT3 FRS2 FRS3 GRB14 GRB2 HTR1A IL17RD ITGB3 ITK KLB KPNB1 L1CAM MFHAS1 MMP2 NCAM1 NCK1 NCK2 NECTIN1 NEDD4 NRP1 PDGFRB PDK1 PDP1 PIK3R1 PIK3R2 PLCG1 PTK6 PTPN1 RARA RASA1 RPS6KA1 RPS6KA3 RTN1 RTN3 SH3BP2 SHC1 SLA SOS1 TNK2 TNS2 VAV1 YES1
Entrez ID		152831	2260
HPRD ID		14097	00634
Ensembl ID		ENSG00000134962	ENSG00000077782
Uniprot IDs		B4DYH5 Q86Z14	A0A0S2Z3Q6 A0A3B3ISD1 P11362
PDB IDs		5VAK 5VAN 5VAQ 5WI9 6NFJ	1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 1XR0 2CR3 2FGI 3C4F 3DPK 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3OJV 3RHX 3TT0 4F63 4F64 4F65 4NK9 4NKA 4NKS 4RWI 4RWJ 4RWK 4RWL 4UWB 4UWC 4UWY 4V01 4V04 4V05 4WUN 4ZSA 5A46 5A4C 5AM6 5AM7 5B7V 5EW8 5FLF 5O49 5O4A 5UQ0 5UR1 5VND 5W21 5W59 5Z0S 5ZV2 6C18 6C19 6C1B 6C1C 6C1O 6ITJ 6MZQ 6MZW 6NVL 6P68 6P69
Enriched GO Terms of Interacting Partners?
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