ADRA2C and EIF2B1

Number of citations of the paper that reports this interaction (PubMedID 9235896)
14

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		ADRA2C	EIF2B1
Description		adrenoceptor alpha 2C	eukaryotic translation initiation factor 2B subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Axon Terminus Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane
	Molecular Function	Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Protein Binding Alpha-2A Adrenergic Receptor Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Behavior Negative Regulation Of Norepinephrine Secretion Platelet Activation Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Receptor Transactivation Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Vasoconstriction Regulation Of Insulin Secretion Regulation Of Sensory Perception Of Pain Negative Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway	Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone T Cell Receptor Signaling Pathway
Pathways		Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism	Recycling of eIF2:GDP
Drugs		Amphetamine Bethanidine Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Norepinephrine Mirtazapine Phenylpropanolamine Loxapine Pramipexole Chlorpromazine Brimonidine Nortriptyline Amoxapine Clonidine Lisuride Epinephrine Tizanidine Apomorphine Risperidone Tolazoline Fenoldopam Dobutamine Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Carvedilol Doxepin Desipramine Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra Mephentermine Yohimbine Methotrimeprazine Methamphetamine Dronedarone Iloperidone OPC-28326 Epicept NP-1 Mianserin Asenapine Droxidopa Esmirtazapine Xylometazoline Levonordefrin Lurasidone Agmatine Brexpiprazole Dosulepin Etoperidone Cirazoline Setiptiline Tiapride
Diseases			Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Blood urea nitrogen levels ( 31152163) Lung cancer in ever smokers ( 28604730) Nickel levels ( 26025379) Urinary potassium excretion ( 31409800)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: EIF2B1 GNAO1 PPP1R9B UCHL1 WFS1 YWHAZ	15 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D BZW2 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MRPL4 NTAQ1 RD3
Entrez ID		152	1967
HPRD ID		00085	09458
Ensembl ID		ENSG00000184160	ENSG00000111361
Uniprot IDs		P18825 Q4W594	Q14232
PDB IDs			3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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